Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

For questions or comments about the database, please contact us through our Contact form.

trichloroethylene (TCE)

CAS number: 79-01-6

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Acute hepatocellular injury (hepatitis)s

Good Evidence

Acute tubular necrosis


Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)

Cardiac congenital malformations

Childhood leukemias


Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Decreased coordination / dysequilibrium

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Hearing loss

Hepatocellular cancer (liver cancer)

Lymphoma (non-Hodgkin's)

Psychiatric disturbances (disorientation, hallucinations, psychosis, delirium, paranoias, anxiety/depression, emotional lability, mood changes, euphoria)

Renal (kidney) cancer


Trigeminal neuropathy

Limited Evidence

ADD/ADHD, hyperactivity

Adult-onset leukemias

Brain cancer - adult

Breast cancer

Cervical cancer

Choanal atresia

Genito-urinary malformations (includes male and female)

Hodgkin's disease (lymphoma)

Immune suppression

Low birth weight / small for gestational age / intra-uterine growth retardation

Lung cancer

Multiple myeloma

Nephrotic syndrome

Neural tube defects / CNS malformations

Oral clefts (cleft lip and palate)

Pancreatic cancer


Peripheral neuropathy

Prostate cancer

Raynaud's phenomenon

Systemic lupus erythematosus

Testicular cancer


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Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Lynge E, Anttila A, Hemminki K. Organic solvents and cancer. Cancer Causes and Control. 1997 May;8(3):406-19.

Maves MD. Epidemiologic studies of environmental agents and systemic autoimmune diseases. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:743-8.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form