Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

For questions or comments about the database, please contact us through our Contact form.

ionizing radiation

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Abnormal sperm (morphology, motility, and sperm count)

Acute hepatocellular injury (hepatitis)s

Adult-onset leukemias

Aplastic anemia

Brain cancer - adult

Brain cancer - childhood

Breast cancer

Childhood leukemias

Congenital malformations - general

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Immune suppression

Lung cancer

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Multiple myeloma

Myelodysplastic syndrome (pre-leukemia)

Reduced fertility - female (infertility and subfertility)

Reduced fertility - male (infertility and subfertility)

Salivary gland cancer

Skin cancer (non-melanoma)

Thyroid cancer

Thyroid disorders - hypothyroidism

Good Evidence

Acute tubular necrosis

Bladder cancer


Colorectal cancer

Cranio-facial malformations

Lymphoma (non-Hodgkin's)


Ovarian cancer

Pancreatic cancer

Stomach cancer

Limited Evidence

ALS (Lou Gehrig's disease)


Multiple sclerosis


Axelson O, Landtblom AM, Flodin U. Multiple sclerosis and ionizing radiation. Neuroepidemiology. 2001 Aug;20(3):175-8.

International Agency for Research on Cancer (IARC). Agents Classified by the IARC Monographs. Accessed in 2010.

Kauppinen T, Partanen T, Degerth R, Ojajärvi A. Pancreatic cancer and occupational exposures. Epidemiology. 1995 Sep;6(5):498-502.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Landrigan PJ, Garg A. Chronic effects of toxic environmental exposures on children's health. Journal of Toxicology. Clinical Toxicology. 2002;40(4):449-56.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form