Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

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ethylene glycol ethers

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Abnormal sperm (morphology, motility, and sperm count)

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Reduced fertility - male (infertility and subfertility)

Good Evidence

Acute tubular necrosis

Congenital malformations - general

Cranio-facial malformations

Reduced fertility - female (infertility and subfertility)

Limited Evidence

Cardiac congenital malformations

Genito-urinary malformations (includes male and female)

Hormonal changes (levels of circulating sex hormones - FSH/LH, Inhibin, and/or estrogens, progesterones, androgens, prolactin)

Immune suppression

Neural tube defects / CNS malformations

Oral clefts (cleft lip and palate)

Skeletal malformations

Testicular cancer


Correa A, Gray RH, Cohen R, Rothman N, Shah F, Seacat H, Corn M. Ethylene glycol ethers and risks of spontaneous abortion and subfertility. American Journal of Epidemiology, 1996. 143(7): p. 707-717.

El-Zein RA, Abdel-Rahman SZ, Morris DL, Legator MS. Exposure to ethylene glycol monomethyl ether: clinical and cytogenetic findings. Archives of Environmental Health. 2002 Jul-Aug;57(4):371-6.

Integrated Risk Information System (IRIS). IRIS Assessments. Accessed in 2010.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Landrigan PJ, Garg A. Chronic effects of toxic environmental exposures on children's health. Journal of Toxicology. Clinical Toxicology. 2002;40(4):449-56.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form