Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

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pentachlorophenol (PCP)

CAS number: 87-86-5

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Acute tubular necrosis

Good Evidence

Aplastic anemia


Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Immune suppression

Low birth weight / small for gestational age / intra-uterine growth retardation

Pancreatic cancer

Renal (kidney) cancer

Limited Evidence

Adrenal cancer

Angiosarcoma (hepatic)

Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)

Brain cancer - adult

Congenital malformations - general

Delayed growth

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Hepatocellular cancer (liver cancer)

Lymphoma (non-Hodgkin's)

Nasopharyngeal / sino-nasal cancer


Reduced fertility - female (infertility and subfertility)

Thrombocytopenic purpura

Thyroid disorders - hypothyroidism


Hruska KS, Furth PA, Seifer DB, Sharara FI, Flaws JA. Environmental factors in infertility. Clinical Obstetrics and Gynecology. 2000 Dec;43(4):821-9.

Jorens PG, Schepens PJ. Human pentachlorophenol poisoning. Human & Experimental Toxicology. 1993 Nov;12(6):479-495.

Khurana V, Barkin JS. Pancreatitis induced by environmental toxins. Pancreas. 2001 Jan; 22(1):102-104.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form