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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

chloroform

CAS number: 67-66-3

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Acute hepatocellular injury (hepatitis)

Acute tubular necrosis

Steatosis (fatty liver)

Good Evidence

Arrhythmias

Developmental toxicity, not otherwise specified

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Porphyria (toxic)

Pre-eclampsia (pregnancy-induced hypertension)

Limited Evidence

Asthma - irritant

Hepatocellular cancer (liver cancer)

Neural tube defects / CNS malformations

Oral clefts (cleft lip and palate)

Renal (kidney) cancer

References

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.

Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986 (California Proposition 65).

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form