Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

For questions or comments about the database, please contact us through our Contact form.


Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Acute hepatocellular injury (hepatitis)s

Acute tubular necrosis

Contact dermatitis - irritant

Olfactory alterations (hyposmia, anosmia, dysomias)

Steatosis (fatty liver)

Good Evidence

Acute tubular necrosis

ADD/ADHD, hyperactivity

Aplastic anemia


Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)

Bladder cancer

Brain cancer - childhood

Breast cancer

Bronchitis - chronic

Cardiac congenital malformations

Cervical cancer


Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Color vision disturbance

Colorectal cancer

Congenital malformations - general

Cranio-facial malformations

Decreased coordination / dysequilibrium

Esophageal cancer

Fetal alcohol syndrome / fetal solvent syndrome

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)


Hearing loss

Low birth weight / small for gestational age / intra-uterine growth retardation

Lung cancer

Lymphoma (non-Hodgkin's)

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Myelodysplastic syndrome (pre-leukemia)

Neurosthenia (organic affective syndrome)

Pancreatic cancer

Porphyria (toxic)

Pre-eclampsia (pregnancy-induced hypertension)

Prostate cancer

Reduced fertility - female (infertility and subfertility)


Stomach cancer

Undifferentiated connective tissue disease

Limited Evidence

Abnormal sperm (morphology, motility, and sperm count)

Acute tubular necrosis

ALS (Lou Gehrig's disease)


Brain cancer - adult

Breast cancer



Chronic fatigue syndrome

Chronic renal disease

Genito-urinary malformations (includes male and female)

Hepatocellular cancer (liver cancer)

Hodgkin's disease (lymphoma)

Immune suppression

Multiple chemical sensitivity

Multiple myeloma

Multiple sclerosis

Multiple sclerosis

Mycosis fungoides (cutaneous T-cell lymphoma)

Nephrotic syndrome

Neural tube defects / CNS malformations

Oral clefts (cleft lip and palate)

Ovarian cancer

Pancreatic cancer

Peripheral neuropathy

Reduced fertility - male (infertility and subfertility)

Renal (kidney) cancer

Rheumatoid arthritis


Stomach cancer

Thrombocytopenic purpura



Aschengrau A, Rogers S, Ozonoff D. Perchloroethylene-contaminated drinking water and the risk of breast cancer: additional results from Cape Cod, Massachusetts, USA. Environmental Health Perspectives. 2003 Feb;111(2):167-73.

Brautbar N. Industrial solvents and kidney disease. International Journal of Occupational and Environmental Health. 2004 Jan-Mar;10(1):79-83.

Buzio L, Tondel M, De Palma G, Buzio C, Franchini I, Mutti A, Axelson O. Occupational risk factors for renal cell cancer: an Italian case-control study. Medicina del Lavoro. 2002 Jul-Aug; 93(4):303-9.

Caress S, Steinemann A. A review of a two-phase population study of multiple chemical sensitivities. Environmental Health Perspectives. 2003; 111(12):1490-1497.

Carpenter DO, Arcaro K, Spink DC. Understanding the human health effects of chemical mixtures. Environmental Health Perspectives. 2002;110(suppl 1):25-42.

Colt JS, Blair A. Parental occupational exposures and risk of childhood cancer. Environmental Health Perspectives. 1998;106(Suppl 3):909-925.

Cooper GS, Miller FW, Germolec DR. Occupational exposures and autoimmune diseases. International Immunopharmacology. 2002;2:303-313.

D'Cruz D. Autoimmune diseases associated with drugs, chemicals and environmental factors. Toxicology Letters. 2000 Mar 15;112-113:421-32.

Eskenazi B, Bracken MB, Holford TR, Grady J. Exposure to organic solvents and hypertensive disorders of pregnancy. American Journal of Industrial Medicine. 1988; 14(2):177-88.

Figà-Talamanca I, Traina ME, Urbani E. Occupational exposures to metals, solvents, and pesticides: recent evidence on male reproductive effects and biological markers. Occupational Medicine (Oxford, England). 2001 May;51(3):174-88.

Freed DM, Kandel E. Long-term exposure and the diagnosis of dementia. NeuroToxicology. 1988 Fall;9(3):391-400.

Hardell L, Lindström G, van Bavel B, Fredrikson M, Liljegren G. Some aspects of the etiology of non-Hodgkin's lymphoma. Environmental Health Perspectives. 1998 Apr;106(Suppl 2):679-681.

Hay A, Singer CRJ. Wood preservatives, solvents, and thrombocytopenic purpura. Lancet. 1991 Sep 21;338(8769):766.

Hruska KS, Furth PA, Seifer DB, Sharara FI, Flaws JA. Environmental factors in infertility. Clinical Obstetrics and Gynecology. 2000 Dec;43(4):821-9.

Kaerlev L, Teglbjaerg PS et al. Occupational risk factors for small bowel carcinoid tumor: a European population-based case-control study. Journal of Occupational and Environmental Medicine. 2002 Jun;44(6):516-22.

Kauppinen T, Partanen T, Degerth R, Ojajärvi A. Pancreatic cancer and occupational exposures. Epidemiology. 1995 Sep;6(5):498-502.

Khattak S, K-Moghtader G, McMartin K, Barrera M, Kennedy D, Koren G. Pregnancy outcome following gestational exposure to organic solvents: a prospective controlled study. Journal of the American Medical Association. 1999 Mar 24-31;281(12):1106-9.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

Kukull WA, Larson EB et al. Solvent exposure as a risk factor for Alzheimer's disease: a case-control study. American Journal of Epidemiology. 1995 Jun 1;141(11):1059-71; discussion 1072-9.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Landrigan PJ, Garg A. Chronic effects of toxic environmental exposures on children's health. Journal of Toxicology. Clinical Toxicology. 2002;40(4):449-56.

Landtblom AM, Flodin U, Söderfeldt B, Wolfson C, Axelson O. Organic solvents and multiple sclerosis: a synthesis of current evidence. Epidemiology 1996;7(4):429-33.

Lane SE, Watts RA, Bentham G, Innes NJ, Scott DG. Are environmental factors important in primary systemic vasculitis? A case-control study. Arthritis and Rheumatism. 2003 Mar;48(3):814-23.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.

Loffredo CA. Epidemiology of cardiovascular malformations: prevalence and risk factors. American Journal of Medical Genetics. 2000 Winter;97(4):319-25.

Maves MD. Epidemiologic studies of environmental agents and systemic autoimmune diseases. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:743-8.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form