Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

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mercury

CAS number: 7439-97-6

Diseases linked to this toxicant Grouped by strength of evidence

Strong Evidence Acute tubular necrosis Behavioral problems Bronchitis - acute Cerebral palsy Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay Contact dermatitis - irritant Decreased coordination / dysequilibrium Hearing loss Minamata disease Peripheral neuropathy Pneumonitis (hypersensitivity) Psychiatric disturbances (disorientation, hallucinations, psychosis, delirium, paranoias, anxiety/depression, emotional lability, mood changes, euphoria) Seizures Spasticity / myoclonus	Good Evidence Altered sex ratio Anemia (including hemolytic) Aplastic anemia Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.) Chronic renal disease Congenital malformations - general Coronary artery disease, peripheral vascular disease, atherosclerosis Cranio-facial malformations Decreased vision (includes blindness, retinopathy, optic neuropathy) Delayed growth Fetotoxicity (miscarriage / spontaneous abortion, stillbirth) Glomerulonephritis Immune suppression Low birth weight / small for gestational age / intra-uterine growth retardation Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods) Neural tube defects / CNS malformations Pneumonia Pulmonary edema	Limited Evidence ALS (Lou Gehrig's disease) Brain cancer - adult Erectile dysfunction Hormonal changes (levels of circulating sex hormones - FSH/LH, Inhibin, and/or estrogens, progesterones, androgens, prolactin) Hypertension (high blood pressure) Myocardial infarction (heart attack) Nephrotic syndrome Neurosthenia (organic affective syndrome) Pulmonary fibrosis Reduced fertility - female (infertility and subfertility) Reduced fertility - male (infertility and subfertility) Renal (kidney) cancer Scleroderma Thyroid disorders - hypothyroidism

References

Carpenter DO, Arcaro K, Spink DC. Understanding the human health effects of chemical mixtures. Environmental Health Perspectives. 2002;110(suppl 1):25-42.

Choy CM, Lam CW, Cheung LT, Briton-Jones CM, Cheung LP, Haines CJ. Infertility, blood mercury concentrations and dietary seafood consumption: a case-control study. BJOG. 2002; 109(10):1121-1125.

Denham M, Schell LM et al. Relationship of lead, mercury, mirex, dichlorodiphenyldichloroethylene, hexachlorobenzene, and polychlorinated biphenyls to timing of menarche among Akwesasne Mohawk girls. Pediatrics. 2005 Feb;115(2):e127-34.

Goyer RA. Environmentally related diseases of the urinary tract. The Medical Clinics of North America. 1990 Mar;74(2):377-89.

Guallar E, Sanz-Gallardo MI et al. Mercury, fish oils, and the risk of myocardial infarction. New England Journal of Medicine. 2002 Nov 28;347(22):1747-54.

Holladay SD. Prenatal immunotoxicant exposure and postnatal autoimmune disease. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:687-91.

Kelleher P, Pacheco K, Newman LS. Inorganic dust pneumonias: the metal-related parenchymal disorders. Environmental Health Perspectives. 2000 Aug;108 Suppl 4:685-96.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Landrigan PJ, Garg A. Chronic effects of toxic environmental exposures on children's health. Journal of Toxicology. Clinical Toxicology. 2002;40(4):449-56.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form

Dig Deeper

Human environmental disease network: a computational model to assess toxicology of contaminants

About This Database

See a description of database methods, definitions and limitations.

Information in this database was originally drawn from these texts:

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill, 2001.
LaDou J. Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.
Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

Further references are or will be posted with the displays of individual toxicants.