Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

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CAS number: 7439-97-6

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Acute tubular necrosis

Behavioral problems

Bronchitis - acute

Cerebral palsy

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Contact dermatitis - irritant

Decreased coordination / dysequilibrium

Hearing loss

Minamata disease

Peripheral neuropathy

Pneumonitis (hypersensitivity)

Psychiatric disturbances (disorientation, hallucinations, psychosis, delirium, paranoias, anxiety/depression, emotional lability, mood changes, euphoria)


Spasticity / myoclonus

Good Evidence

Altered sex ratio

Anemia (including hemolytic)

Aplastic anemia

Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)

Chronic renal disease

Congenital malformations - general

Coronary artery disease, peripheral vascular disease, atherosclerosis

Cranio-facial malformations

Decreased vision (includes blindness, retinopathy, optic neuropathy)

Delayed growth

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)


Immune suppression

Low birth weight / small for gestational age / intra-uterine growth retardation

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Neural tube defects / CNS malformations


Pulmonary edema

Limited Evidence

ALS (Lou Gehrig's disease)

Brain cancer - adult

Erectile dysfunction

Hormonal changes (levels of circulating sex hormones - FSH/LH, Inhibin, and/or estrogens, progesterones, androgens, prolactin)

Hypertension (high blood pressure)

Myocardial infarction (heart attack)

Nephrotic syndrome

Neurosthenia (organic affective syndrome)

Pulmonary fibrosis

Reduced fertility - female (infertility and subfertility)

Reduced fertility - male (infertility and subfertility)

Renal (kidney) cancer


Thyroid disorders - hypothyroidism


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Denham M, Schell LM et al. Relationship of lead, mercury, mirex, dichlorodiphenyldichloroethylene, hexachlorobenzene, and polychlorinated biphenyls to timing of menarche among Akwesasne Mohawk girls. Pediatrics. 2005 Feb;115(2):e127-34.

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Guallar E, Sanz-Gallardo MI et al. Mercury, fish oils, and the risk of myocardial infarction. New England Journal of Medicine. 2002 Nov 28;347(22):1747-54.

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LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Landrigan PJ, Garg A. Chronic effects of toxic environmental exposures on children's health. Journal of Toxicology. Clinical Toxicology. 2002;40(4):449-56.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form