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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

mercury

CAS number: 7439-97-6

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Acute tubular necrosis

Behavioral problems

Bronchitis - acute

Cerebral palsy

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Contact dermatitis - irritant

Decreased coordination / dysequilibrium

Hearing loss

Minamata disease

Peripheral neuropathy

Pneumonitis (hypersensitivity)

Psychiatric disturbances (disorientation, hallucinations, psychosis, delirium, paranoias, anxiety/depression, emotional lability, mood changes, euphoria)

Seizures

Spasticity / myoclonus

Good Evidence

Altered sex ratio

Anemia (including hemolytic)

Aplastic anemia

Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)

Chronic renal disease

Congenital malformations - general

Coronary artery disease, peripheral vascular disease, atherosclerosis

Cranio-facial malformations

Decreased vision (includes blindness, retinopathy, optic neuropathy)

Delayed growth

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Glomerulonephritis

Immune suppression

Low birth weight / small for gestational age / intra-uterine growth retardation

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Neural tube defects / CNS malformations

Pneumonia

Pulmonary edema

Limited Evidence

ALS (Lou Gehrig's disease)

Brain cancer - adult

Erectile dysfunction

Hormonal changes (levels of circulating sex hormones - FSH/LH, Inhibin, and/or estrogens, progesterones, androgens, prolactin)

Hypertension (high blood pressure)

Myocardial infarction (heart attack)

Nephrotic syndrome

Neurosthenia (organic affective syndrome)

Pulmonary fibrosis

Reduced fertility - female (infertility and subfertility)

Reduced fertility - male (infertility and subfertility)

Renal (kidney) cancer

Scleroderma

Thyroid disorders - hypothyroidism

References

Carpenter DO, Arcaro K, Spink DC. Understanding the human health effects of chemical mixtures. Environmental Health Perspectives. 2002;110(suppl 1):25-42.

Choy CM, Lam CW, Cheung LT, Briton-Jones CM, Cheung LP, Haines CJ. Infertility, blood mercury concentrations and dietary seafood consumption: a case-control study. BJOG. 2002; 109(10):1121-1125.

Denham M, Schell LM et al. Relationship of lead, mercury, mirex, dichlorodiphenyldichloroethylene, hexachlorobenzene, and polychlorinated biphenyls to timing of menarche among Akwesasne Mohawk girls. Pediatrics. 2005 Feb;115(2):e127-34.

Goyer RA. Environmentally related diseases of the urinary tract. The Medical Clinics of North America. 1990 Mar;74(2):377-89.

Guallar E, Sanz-Gallardo MI et al. Mercury, fish oils, and the risk of myocardial infarction. New England Journal of Medicine. 2002 Nov 28;347(22):1747-54.

Holladay SD. Prenatal immunotoxicant exposure and postnatal autoimmune disease. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:687-91.

Kelleher P, Pacheco K, Newman LS. Inorganic dust pneumonias: the metal-related parenchymal disorders. Environmental Health Perspectives. 2000 Aug;108 Suppl 4:685-96.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Landrigan PJ, Garg A. Chronic effects of toxic environmental exposures on children's health. Journal of Toxicology. Clinical Toxicology. 2002;40(4):449-56.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form