Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

See also our compilation of other Databases and Resources

For questions or comments about the database, please contact us through our Contact form.


Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Acute tubular necrosis

Asthma - allergen, sensitizer

Bronchitis - acute

Contact dermatitis - irritant

Nasal polyps

Nasal septal perforation

Pneumonitis (hypersensitivity)

Rhinitis - allergic

Skin ulceration

Good Evidence

Brain cancer - adult

Chronic renal disease

COPD (chronic obstructive pulmonary disease)


Pulmonary fibrosis

Stomach cancer

Limited Evidence

Abnormal sperm (morphology, motility, and sperm count)

Adult-onset leukemias

Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)

Bladder cancer

Esophageal cancer

Immune suppression

Pancreatic cancer

Prostate cancer

Reduced fertility - male (infertility and subfertility)

Renal (kidney) cancer

Soft tissue sarcomas


Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikauf GD. Hazardous air pollutants and asthma. Environmental Health Perspectives. 2002 Aug;110 Suppl 4:505-26.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form