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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

cadmium

CAS number: 7440-43-9

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Acute tubular necrosis

Chronic renal disease

Itai-itai disease

Lung cancer

Olfactory alterations (hyposmia, anosmia, dysomias)

Osteoporosis

Pneumonitis (hypersensitivity)

Renal stones

Good Evidence

Anemia (including hemolytic)

Cardiomyopathy

COPD (chronic obstructive pulmonary disease)

Coronary artery disease, peripheral vascular disease, atherosclerosis

Hormonal changes (levels of circulating sex hormones - FSH/LH, Inhibin, and/or estrogens, progesterones, androgens, prolactin)

Nephrotic syndrome

Osteomalacia

Pneumonia

Reduced fertility - male (infertility and subfertility)

Limited Evidence

Abnormal sperm (morphology, motility, and sperm count)

ADD/ADHD, hyperactivity

Arrhythmias

Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)

Brain cancer - adult

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Cranio-facial malformations

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Genito-urinary malformations (includes male and female)

Hypertension (high blood pressure)

Hypoactivity

Immune suppression

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Metal fume fever

Neural tube defects / CNS malformations

Oral clefts (cleft lip and palate)

Pancreatic cancer

Peripheral neuropathy

Prostate cancer

Pulmonary edema

Pulmonary fibrosis

Renal (kidney) cancer

Soft tissue sarcoma

Testicular cancer

References

Balmes J, Becklake M et al. American Thoracic Society Statement: Occupational contribution to the burden of airway disease. American Journal of Respiratory and Critical Care Medicine. 2003 Mar 1;167(5):787-97.

Carpenter DO, Arcaro K, Spink DC. Understanding the human health effects of chemical mixtures. Environmental Health Perspectives. 2002;110(suppl 1):25-42.

Gottschall EB. Occupational and environmental thoracic malignancies. Journal of Thoracic Imaging. 2002 Jul; 17:189-197.

Goyer RA. Environmentally related diseases of the urinary tract. The Medical Clinics of North America. 1990 Mar;74(2):377-89.

Holladay SD. Prenatal immunotoxicant exposure and postnatal autoimmune disease. Environmental Health Perspectives. 1999 Oct;107 Suppl 5:687-91.

Hu J, Mao Y, White K. Renal cell carcinoma and occupational exposure to chemicals in Canada. Occupational Medicine (Oxford, England). 2002 May;52(3):157-64.

International Agency for Research on Cancer (IARC). Agents Classified by the IARC Monographs. Accessed in 2010.

Kelleher P, Pacheco K, Newman LS. Inorganic dust pneumonias: the metal-related parenchymal disorders. Environmental Health Perspectives. 2000 Aug;108 Suppl 4:685-96.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikauf GD. Hazardous air pollutants and asthma. Environmental Health Perspectives. 2002 Aug;110 Suppl 4:505-26.

Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form