Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.

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CAS number: 7440-43-9

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Acute tubular necrosis

Chronic renal disease

Itai-itai disease

Lung cancer

Olfactory alterations (hyposmia, anosmia, dysomias)


Pneumonitis (hypersensitivity)

Renal stones

Good Evidence

Anemia (including hemolytic)


COPD (chronic obstructive pulmonary disease)

Coronary artery disease, peripheral vascular disease, atherosclerosis

Hormonal changes (levels of circulating sex hormones - FSH/LH, Inhibin, and/or estrogens, progesterones, androgens, prolactin)

Nephrotic syndrome



Reduced fertility - male (infertility and subfertility)

Limited Evidence

Abnormal sperm (morphology, motility, and sperm count)

ADD/ADHD, hyperactivity


Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)

Brain cancer - adult

Cognitive impairment (includes impaired learning, impaired memory, and decreased attention span) / mental retardation / developmental delay

Cranio-facial malformations

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Genito-urinary malformations (includes male and female)

Hypertension (high blood pressure)


Immune suppression

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Metal fume fever

Neural tube defects / CNS malformations

Oral clefts (cleft lip and palate)

Pancreatic cancer

Peripheral neuropathy

Prostate cancer

Pulmonary edema

Pulmonary fibrosis

Renal (kidney) cancer

Soft tissue sarcomas

Testicular cancer


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International Agency for Research on Cancer (IARC). Agents Classified by the IARC Monographs. Accessed in 2010.

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Leikin JB, Davis A, Klodd DA, Thunder T, Kelafant GA, Paquette DL, Rothe MJ, Rubin R. Selected topics related to occupational exposures. Part V. Occupational cardiovascular disease. Disease-a-Month. 2000 Apr;46(4):311-322.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form