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Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and its limitations.

See also CHE's compilation of other Databases and Resources

For questions or comments about the database, please contact Nancy Hepp through our Contact form.

2,4-D

CAS number: 94-75-7

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Chloracne

Good Evidence

Abnormal sperm (morphology, motility, and sperm count)

Lymphoma (non-Hodgkin's)

Peripheral neuropathy

Porphyria (toxic)

Soft tissue sarcoma

Limited Evidence

Acute hepatocellular injury (hepatitis)

Brain cancer - adult

Cholestasis

Colorectal cancer

Immune suppression

Neural tube defects / CNS malformations

Oral clefts (cleft lip and palate)

Reduced fertility - male (infertility and subfertility)

Testicular cancer

References

Arbuckle T, Lin Z, Mery LS. An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population. Environmental Health Perspectives. 2001 Aug;109(8):851-7.

Flower KB, Hoppin JA, Lynch CF, Blair A, Knott C, Shore DL, Sandler DP. Cancer risks and parental pesticide application in children of Agricultural Health Study participants. Environmental Health Perspectives. 2004 Apr;112(5):631-635.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Morris Brown L, Blair A, Gibson R, Everett GD, Cantor KP et al. Pesticide exposures and other agricultural risk factors for leukemia among men in Iowa and Minnesota. Cancer Research. 1990 Oct;50(20):6585-6591.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.

NOTE: Not all the references are currently available, but they will be added as soon as possible. If you need a reference and are unable to find it, please contact us through our contact form