Multi- and transgenerational outcomes of an exposure to a mixture of EDCs on puberty and maternal behavior in the female rat
12:00 pm US Eastern Time
López-Rodríguez, D., Aylwin, C.F., Delli, V., Sevrin, E., Campanile, M., Martin, M., Franssen, D., Gérard, A., Blacher, S., Tirelli, E., Noël, A., Lomniczi, A., Parent, AS. (2021). Multi- and transgenerational outcomes of an exposure to a mixture of Endocrine Disrupting Chemicals (EDCs) on puberty and maternal behavior in the female rat. Environ Health Perspect. 129(8). doi: 10.1289/EHP8795.
University of Liège, Belgium: Laboratory of Neuroendocrinology.
During this webinar Dr. Anne-Simone Parent will present a new study that explored the effects of a complex mixture of estrogenic and anti-androgenic compounds on the hypothalamic control of puberty and reproduction. Female rats (F0 generation) were orally exposed to a mixture of 14 anti-androgenic and estrogenic EDCs or corn oil for 2 weeks before and throughout gestation and until weaning. F2 and F3 rats ancestrally exposed to the EDC mixture exhibited transgenerational disruption of sexual maturation and multigenerational alterations of maternal care via hypothalamic epigenetic reprogramming. These results raise concerns about the impact of EDC mixtures on future generations.
This webinar is one in a monthly series sponsored by the Collaborative on Health and the Environment’s EDC Strategies Partnership. The CHE EDC Strategies Partnership is chaired by Sharyle Patton (Commonweal Biomonitoring Resource Center), Jerry Heindel (Commonweal HEEDS, Healthy Environment and Endocrine Disruptor Strategies), Genon Jensen (HEAL), Sarah Howard (DiabetesandEnvironment.org), and Hannah Donart (Collaborative on Health and the Environment, a Commonweal program). To see a full list of past calls and webinars related to EDCs and listen to or view recordings, please visit our partnership page.
This webinar will be moderated by Jerry Heindel, PhD, founder and director of Commonweal's Healthy Environment and Endocrine Disruptor Strategies (HEEDS). It will last for 40 minutes and will be recorded for our call and webinar archive.
Anne-Simone Parent, PhD, received her medical degree and PhD in Biomedical Science from the University of Liège, Belgium. After a three-year postdoctoral stay in SR Ojeda’s laboratory at Oregon Health and Science University where she studied the molecular determinants of the hypothalamic control of puberty, she became an Associate Researcher at the Belgian National Foundation for Research. Currently, Dr. Parent is an Associate Professor in Padiatric Endocrinology at the University of Liège, Belgium and a Principal Investigator at GIGA-Neurosciences, University of Liège. Being a padiatric endocrinologist, her studies have always focused on bridging clinical and laboratory research. For the last 15 years, the group has developed models to study the effects of endocrine disrupting chemicals on the central nervous system and focuses on their effects on the hypothalamic control of puberty and reproduction and on hippocampus development.