DOHaD and EDCs: Past, Present, and Future
1:00 pm US Eastern Time
Slides & Resources
Jerry Heindel: DOHaD and EDCs: Past, Present, and Future
Epigenetics as a mechanism linking developmental exposures to long-term toxicity.
Barouki R, Melén E, Herceg Z, Beckers J, Chen J, Karagas M, Puga A, Xia Y, Chadwick L, Yan W, Audouze K, Slama R, Heindel J, Grandjean P, Kawamoto T, Nohara K.
Environ Int. 2018 May;114:77-86.
Developmental Origins of Health Span and Life Span: A Mini-Review.
Preston JD, Reynolds LJ, Pearson KJ.
Bisphenol-A treatment during pregnancy in mice: a new window of susceptibility for the development of diabetes in mothers later in life.
Alonso-Magdalena P, García-Arévalo M, Quesada I, Nadal Á.
Endocrinology. 2015 May;156(5):1659-70.
Bisphenol S (BPS) Alters Maternal Behavior and Brain in Mice Exposed During Pregnancy/Lactation and Their Daughters.
Catanese MC, Vandenberg LN.
Endocrinology. 2017 Mar 1;158(3):516-530.
Germline and reproductive tract effects intensify in male mice with successive generations of estrogenic exposure.
Horan TS, Marre A, Hassold T, Lawson C, Hunt PA.
PLoS Genet. 2017
Fathers Matter: Why It's Time to Consider the Impact of Paternal Environmental Exposures on Children's Health.
Braun JM, Messerlian C, Hauser R.
Curr Epidemiol Rep. 2017 Mar;4(1):46-5.
Perinatal BPA exposure alters body weight and composition in a dose specific and sex specific manner: The addition of peripubertal exposure exacerbates adverse effects in female mice.
Rubin BS, Paranjpe M, DaFonte T, Schaeberle C, Soto AM, Obin M, Greenberg AS.
Reprod Toxicol. 2017 Mar;68:130-144.
Metabolism disrupting chemicals and metabolic disorders.
Heindel JJ, Blumberg B, Cave M, Machtinger R, Mantovani A, Mendez MA, Nadal A, Palanza P, Panzica G, Sargis R, Vandenberg LN, Vom Saal F.
Reprod Toxicol. 2017 Mar;68:3-33.
In 2008 Jerry Heindel, PhD, Director of the Program on Endocrine Disruption Strategies at Commonweal, presented an overview of the Developmental Origins of Health and Disease (DOHaD) field, focusing on environmental chemical exposures. At that time the field was just getting off the ground, with a focus on developmental exposure to a small number of endocrine disrupting chemicals (EDCs) and disease outcomes across the lifespan in animal models and human birth cohort studies.
The PPTox (Prenatal Programming and Toxicity) field has changed significantly over the last decade. There are new windows of susceptibility including preconception and prepuberty, a focus on the mother and not just the offspring, and a major focus on epigenetic transgenerational inheritance. Whole new disease focus areas have sprung up including obesity, type 2 diabetes, and fatty liver disease--all with a connection to developmental exposures to EDCs now called obesogens or metabolism disruptors. There is also a focus on the study of new EDCs, mixtures, molecular mechanisms, the development of new biomarkers of exposure, and studies focusing on intervention and prevention.
This presentation provided a high-level overview of some of these new research areas that have developed over the last decade, with a focus on animal model studies. The study of EDCs and the DOHaD field have changed significantly over the last decade, leading to improved impacts to reduce disease and dysfunction.
Jerrold (Jerry) J. Heindel has a PhD in Biochemistry from the University of Michigan and worked in the area of reproductive biology and toxicology while on the faculty at the University of Texas Medical School at Houston and the University of Mississippi. He moved to the National Institute of Environmental Health Sciences (NIEHS) in Research Triangle Park, NC to head their Reproductive and Developmental Toxicology group. Twenty five years ago he moved to the Division of Extramural Research and Training at NIEHS where he was a Scientific Program Administrator and responsible for developing and administering the NIEHS grants program in endocrine disruptors, developmental basis of diseases, and obesity and diabetes. He developed research initiatives in the areas of endocrine disruptors, the role of environmental chemicals in the developmental origins of disease, and the role of environmental chemicals in obesity and diabetes. Over the past 25 years he has given over 125 invited presentations across the globe and published over 70 reviews and book chapters, mostly related to endocrine disruptors and the developmental origins of disease. He is now retired from NIEHS and is currently the director of the Commonweal Program on Endocrine Disruption Strategies, and the director of a business to help scientists write grants for NIH, Grantsmanship Strategies.
This webinar is one in a monthly series sponsored by the Collaborative on Health and the Environment’s EDC Strategies Partnership. The CHE EDC Strategies Partnership is chaired by Carol Kwiatkowski and Katie Pelch (TEDX), Sharyle Patton (Commonweal Biomonitoring Resource Center), Jerry Heindel (Commonweal Program on Endocrine Disruption Strategies), and Genon Jensen (HEAL) and coordinated by Maria Williams (Collaborative on Health and the Environment, a Commonweal program). To see a full list of past calls and webinars related to EDCs and listen to or view recordings, please visit our partnership page.
This webinar was moderated by Sharyle Patton, director of Commonweal’s Biomonitoring Resource Center. It lasted for 30 minutes and was recorded for our call and webinar archive.