Exposure to Per- and Polyfluoroalkyl Substances and Markers of Liver Injury

September 14, 2022
1:00 pm US Eastern Time

Slides & Resources


PFAS-Liver Webinar, Dr. Lida Chatzi, Sept 14 2022


Costello, E., Rock, S., Stratakis, S., et al. (2022). Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis. Environ. Health Perspect. 130(4). doi:10.1289/EHP10092.




Per- and polyfluoroalkyl substances (PFAS) are very persistent and ubiquitous in our environment. They are used in many industrial and consumer products and bioaccumulate in the food chain and in humans. During this webinar Dr. Vaia Lida Chatzi presented a new systematic review and meta-analysis looking at the weight and strength of the evidence of 85 animal and 24 human studies investigating exposure to PFAS and markers of liver injury. The study found that there is consistent evidence linking PFAS exposure to liver injury in both rodents and humans. The webinar will conclude with a discussion on paths forward for future research looking at next-generation PFAS, mixtures, and potential developmental effects, as well as policy implications.

This webinar was moderated by Jerry Heindel, PhD, founder and director of Environmental Health Sciences' (EHS) Healthy Environment and Endocrine Disruption Strategies (HEEDS). It lasted for 45 minutes and was recorded for the CHE webinar archive.

This webinar series is sponsored by the EDC Strategies Partnership. The EDC Strategies Partnership is co-chaired by Sharyle Patton (Commonweal Biomonitoring Resource Center), Jerry Heindel and Sarah Howard (Environmental Health Sciences' Healthy Environment and Endocrine Disruptor Strategies HEEDS), Genon Jensen (Health and Environment Alliance, HEAL), and Kristin Schafer (Commonweal CHE, Collaborative on Health and the Environment). To see a full list of past calls and webinars related to EDCs and listen to or view recordings, please visit our partnership page. For updates and more information on upcoming webinars, sign up for our HEEDSHEAL, and CHE newsletters! 

Featured Speaker

Dr Chatzi is a physician-environmental epidemiologist with expertise in birth cohort research. Her research focuses on the influence of nutrition and obesogenic chemical exposures during pregnancy and early childhood on long-term maternal and child health, especially obesity, asthma and cognitive development. She has published widely on the effects of early life exposure to endocrine disrupting chemicals on obesity and metabolic outcomes in children. In support of this work, she has led studies examining maternal and infant diet and their associations with the risk of adiposity and asthma in childhood. She is the principal investigator and co-leader of the “Rhea” pregnancy cohort in Greece and she has had significant leadership roles in major cohort studies studying environmental exposures early in life.