Log in - Help - June 26, 2016
CHE logo The Collaborative on Health and the Environment
This site WWW
PARTNERSHIP EVENTS

CHE Partnership call: Using Science to Set Regulatory Criteria: Identifying Endocrine Disrupting Chemicals in the European Union
Wed, June 29
Hosted by the EDCs Working Group
 

CHE Partnership call: Interactive Effects of Multiple Pesticides on Human Health – A 2016 California Report
Thurs, July 7
 

CHE Partnership call: A Consensus on the Environmental Chemicals Contributing to Neurodevelopmental Disorders: Project TENDR
Tues, July 12
 

CHE Partnership call: TSCA Reform: Understanding the Science, Implementation, and Implications of the New Chemical Safety Act
Wed, July 13
 

CHE Partnership call: Autism Pathways Analysis: A Functional Framework and Clues for Further Investigation
Thurs, July 21
 

CHE Partnership call: Fatty Bones Make Bad Skeletons: Influence of Bone-disrupting Chemicals across the Lifespan
Tues, July 26
 

6/22/16: Clarifying EMF and Cancer: Precautionary Occupational Strategies and Results of the NTP Cell Phone Studies
This call was not recorded


6/15/16: MP3 recording available: Mercury in the North: Sources of Contamination and International Policies to Protect Health & Human Rights

 

6/7/16: MP3 recording available: Exploring Multifactorial Contributors to Disease Outcomes: The Possible Role of Acetaminophen in Asthma and Autism


5/24/16: MP3 recording available: The Human Microbiome and Health Effects on Prenatal Microbiome Exposure

 

5/18/16: MP3 recording available: Signaling Mechanisms by Which Xenoestrogen Pollutants Disrupt Normal Estrogenic Signaling


***

CHE Partners on why they value our work

Transgenerational Effects of Prenatal Exposure to Environmental Obesogens in Rodents

Mar 20, 2013

This call was hosted by the CHE Diabetes-Obesity Spectrum and CHE Fertility and Reproductive Health Working Groups

Accumulating scientific research suggests that exposure to environmental chemicals early in life can affect the risk of obesity in later life. Chemicals that can increase the risk of obesity are known as “obesogens.” Two recently published animal studies take obesogen research one step further: both found that the obesity-related effects of prenatal exposure to environmental chemicals were passed down to the third generation descendants of the exposed animals.

On this call we heard the authors of these studies discuss their results. Dr. Bruce Blumberg, who coined the term “obesogen” and has done extensive research on the topic, discussed his work on prenatal exposure to the obesogen tributyltin and its effects on fat cells in mice and their offspring. Dr. Michael Skinner, who has conducted extensive research on the transgenerational effects of various chemical exposures, discussed his findings on the transgenerational effects in rats of prenatal exposure to a mixture of BPA and phthalates.

This call was moderated by Sarah Howard, National Coordinator, CHE Diabetes-Obesity Spectrum Working Group, and Karin Russ, National Coordinator, CHE Fertility and Reproductive Health Working Group.

Featured speakers:

Bruce Blumberg, PhD, is a professor in the Department of Developmental and Cell Biology at the University of California, Irvine. Dr. Blumberg’s laboratory investigates the role of nuclear hormone receptors in development, physiology and disease. Dr. Blumberg and his colleagues originated the obesogen hypothesis which holds that developmental exposure to endocrine disrupting chemicals (EDCs) can induce permanent physiological changes. EDC exposure elicits epigenetic alterations in gene expression that reprograms the fate of mesenchymal stem cells, predisposing them to become fat cells. Exposed animals develop more and larger fat cells, despite normal diet and exercise, which is likely to lead to weight gain and obesity over time.
 

Michael Skinner, PhD, is a professor in the School of Biological Sciences at Washington State University. Dr. Skinner’s research is focused on the investigation of how different cell types in a tissue interact and communicate to regulate gonadal growth and differentiation, with emphasis in the area of reproductive biology. Recent studies have elucidated several critical events in the initiation of male sex differentiation, testis development and ovarian primordial follicle development. His current research has demonstrated the ability of endocrine disrupting chemicals to promote transgenerational epigenetic disease phenotypes due to abnormal germ line programming in gonadal development.

 

The Collaborative on Health and the Environment
c/o Commonweal, PO Box 316, Bolinas, CA 94924
For questions or comments about the website, email: info@healthandenvironment.org