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The Dose Versus the Poison: "Low-Dose" Effects of Environmental Chemicals

Jul 19, 2012

Earlier this year, a landmark paper appeared titled Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses, published in Endocrine Reviews, a journal of the prestigious Endocrine Society. In this 78-page review, supported by 845 references, twelve leading environmental health researchers  challenge the dogma of “the dose makes the poison,” noting that endocrine-disrupting chemicals (EDCs) can have effects at low doses that are not predicted by effects at higher doses, and noting that fundamental changes in chemical testing and safety determination are needed to protect human health. The paper has received much attention.

On this call, three of the authors of this paper summarized their work and responses to it.

Featured speakers:

John Peterson Myers, PhD
, Founder, CEO and Chief Scientist, Environmental Health Sciences, Charlottesville, Virginia 

Laura N. Vandenberg, PhD, Postdoctoral Fellow at the Center for Regenerative and Developmental Biology and Department of Biology (L.N.V.), Tufts University

R. Thomas Zoeller, PhD, Professor, Biology Department, University of Massachusetts-Amherst, Amherst, Massachusetts

A science update was provided by Ted Schettler, MD, MPH, CHE Science Director, and Science Director of the Science and Environmental Health Network.

The call was moderated by Steve Heilig, CHE Director of Public Health & Education, and Director of Public Health & Education, San Francisco Medical Society.

 

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