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Toxicant and Disease Database

 

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. In 2025, we have also added links to information available in the Comparative Toxicogenomics Database (CTD). See a full description of the database and our methodology. 

See also our compilation of other Databases and Resources.

For questions or comments about the database, please contact us through our Contact form.

 

Anemia (including hemolytic)

Causes    Grouped by strength of evidence

Strong Evidence

anilines

arsine

benzene

copper

lead

stibene (antimony)

TNT (trinitrotoluene)

Good Evidence

arsenic

cadmium

mercury

naphthalene

stibene (antimony)

trimellitic anhydride

Notes

Arsine gas is produced when acid comes into contact with a metal containing arsenic and is used in crystal formation and in the semiconductor industry. Lead causes an acquired deficiency in pyrimidine-5' nucleoidase and severe toxicity is seen in individuals with the hereditary form of this deficiency. Naphthalene toxicity occurs most frequently in individuals with G6PD deficiency.

ADDITIONAL DATA: The toxicant–disease relationships  shown above were last updated in 2011. The relationships shown here are still valid, but additional research has been conducted since that time. Additional research on this disease can be found at this link:

COMPARATIVE TOXICOGENOMICS DATABASE: CURATED RESULTS
Anemia

This link will direct your search to an external database, the Comparative Toxicogenomics Database (CTD). This database is different from, and complementary to, our database.

More information about sources and methods

  • CHE’s Toxicant and Disease Database evaluates existing evidence and categorizes that evidence based on its strength. It is constructed using expert judgment and epidemiological causal inference.
  • The CTD, in contrast, is a continually updated resource that presents information on a broad range of literature on chemical-disease relationships. It also provides data on genes, biological processes, and phenotypes related to chemicals and diseases. It does not categorize information based on strength of evidence,  include an expert judgment process, or draw causal conclusions about toxicant-disease relationships.
  • The link we have provided on this page goes directly to CTD's curated results, which are a subset of the information available through CTD. Curated results in CTD are those for which studies are available on the toxicant-disease relationship.