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Toxicant & Disease Database

Toxicant and Disease Database

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. In 2025, we have also added links to information available in the Comparative Toxicogenomics Database (CTD). See a full description of the database and our methodology.

See also our compilation of other Databases and Resources.

For questions or comments about the database, please contact us through our Contact form.

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Aplastic anemia

Causes Grouped by strength of evidence

Strong Evidence benzene ionizing radiation	Good Evidence arsenic carbon tetrachloride dichlorvos ethylene glycols gold hydrocarbons kerosene mercury pentachlorophenol (PCP) pesticides propoxur solvents TNT (trinitrotoluene)	Limited Evidence bismuth chlordane DDT/DDE dinitrophenols lindane organochlorine pesticides organophosphates parathion perchlorate pesticides

Notes

There are large variations in susceptibility to aplastic anemia which are poorly understood. In addition to the pesticides listed, unspecified pesticide exposure in applicators, manufacturers, and agricultural workers has been associated with aplastic anemia. In these situations, the individual is exposed to mixtures of pesticides or different pesticides at different times and associations between a specific pesticide exposure and disease can not be made.

ADDITIONAL DATA: The toxicant–disease relationships shown above were last updated in 2011. The relationships shown here are still valid, but additional research has been conducted since that time. Additional research on this disease can be found at this link:

COMPARATIVE TOXICOGENOMICS DATABASE: CURATED RESULTS
Anemia, Aplastic

This link will direct your search to an external database, the Comparative Toxicogenomics Database (CTD). This database is different from, and complementary to, our database.

More information about sources and methods

CHE’s Toxicant and Disease Database evaluates existing evidence and categorizes that evidence based on its strength. It is constructed using expert judgment and epidemiological causal inference.
The CTD, in contrast, is a continually updated resource that presents information on a broad range of literature on chemical-disease relationships. It also provides data on genes, biological processes, and phenotypes related to chemicals and diseases. It does not categorize information based on strength of evidence, include an expert judgment process, or draw causal conclusions about toxicant-disease relationships.
The link we have provided on this page goes directly to CTD's curated results, which are a subset of the information available through CTD. Curated results in CTD are those for which studies are available on the toxicant-disease relationship.