[X] CLOSEMAIN MENU

[X] CLOSEIN THIS SECTION

Toxicant and Disease Database

 

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. In 2025, we have also added links to information available in the Comparative Toxicogenomics Database (CTD). See a full description of the database and our methodology. 

See also our compilation of other Databases and Resources.

For questions or comments about the database, please contact us through our Contact form.

 

ionizing radiation

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Abnormal sperm (morphology, motility, and sperm count)

Acute hepatocellular injury (hepatitis)

Adult-onset leukemias

Aplastic anemia

Brain cancer - adult

Brain cancer - childhood

Breast cancer

Childhood leukemias

Congenital malformations - general

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Immune suppression

Lung cancer

Menstrual disorders (abnormal bleeding, short cycles, long cycles, irregular cycles, painful periods)

Multiple myeloma

Myelodysplastic syndrome (pre-leukemia)

Reduced fertility - female (infertility and subfertility)

Reduced fertility - male (infertility and subfertility)

Salivary gland cancer

Skin cancer (non-melanoma)

Thyroid cancer

Thyroid disorders - hypothyroidism

Good Evidence

Acute tubular necrosis

Bladder cancer

Cataracts

Colorectal cancer

Cranio-facial malformations

Lymphoma (non-Hodgkin's)

Mesothelioma

Ovarian cancer

Pancreatic cancer

Stomach cancer

Limited Evidence

ALS (Lou Gehrig's disease)

Endometriosis

Multiple sclerosis

ADDITIONAL DATA: The toxicant–disease relationships  shown above were last updated in 2011. The relationships shown here are still valid, but additional research has been conducted since that time. Additional research on this toxicant can be found at this link:

COMPARATIVE TOXICOGENOMICS DATABASE: CURATED RESULTS
ionizing radiation

This link will direct your search to an external database, the Comparative Toxicogenomics Database (CTD). This database is different from, and complementary to, our database.

More information about sources and methods

  • CHE’s Toxicant and Disease Database evaluates existing evidence and categorizes that evidence based on its strength. It is constructed using expert judgment and epidemiological causal inference.
  • The CTD, in contrast, is a continually updated resource that presents information on a broad range of literature on chemical-disease relationships. It also provides data on genes, biological processes, and phenotypes related to chemicals and diseases. It does not categorize information based on strength of evidence,  include an expert judgment process, or draw causal conclusions about toxicant-disease relationships.
  • The link we have provided on this page goes directly to CTD's curated results, which are a subset of the information available through CTD. Curated results in CTD are those for which studies are available on the toxicant-disease relationship.

References for our 2011 disease list

Axelson O, Landtblom AM, Flodin U. Multiple sclerosis and ionizing radiation. Neuroepidemiology. 2001 Aug;20(3):175-8.

International Agency for Research on Cancer (IARC). Agents Classified by the IARC Monographs. Accessed in 2010.

Kauppinen T, Partanen T, Degerth R, Ojajärvi A. Pancreatic cancer and occupational exposures. Epidemiology. 1995 Sep;6(5):498-502.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Landrigan PJ, Garg A. Chronic effects of toxic environmental exposures on children's health. Journal of Toxicology. Clinical Toxicology. 2002;40(4):449-56.

Leikin JB, Davis A et al. Selected topics related to occupational exposures. Part IV. Occupational liver disease. Disease-a-Month. 2000 Apr;46(4):296-310.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.