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Toxicant and Disease Database

 

The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. In 2025, we have also added links to information available in the Comparative Toxicogenomics Database (CTD). See a full description of the database and our methodology. 

See also our compilation of other Databases and Resources.

For questions or comments about the database, please contact us through our Contact form.

 

ethylene glycol ethers

Diseases linked to this toxicant    Grouped by strength of evidence

Strong Evidence

Abnormal sperm (morphology, motility, and sperm count)

Fetotoxicity (miscarriage / spontaneous abortion, stillbirth)

Reduced fertility - male (infertility and subfertility)

Good Evidence

Acute tubular necrosis

Congenital malformations - general

Cranio-facial malformations

Reduced fertility - female (infertility and subfertility)

Limited Evidence

Cardiac congenital malformations

Genito-urinary malformations (includes male and female)

Hormonal changes (levels of circulating sex hormones - FSH/LH, Inhibin, and/or estrogens, progesterones, androgens, prolactin)

Immune suppression

Neural tube defects / CNS malformations

Oral clefts (cleft lip and palate)

Skeletal malformations

Testicular cancer

ADDITIONAL DATA: The toxicant–disease relationships  shown above were last updated in 2011. The relationships shown here are still valid, but additional research has been conducted since that time. Additional research on this toxicant can be found at this link:

COMPARATIVE TOXICOGENOMICS DATABASE: CURATED RESULTS
ethylene glycol ethers

This link will direct your search to an external database, the Comparative Toxicogenomics Database (CTD). This database is different from, and complementary to, our database.

More information about sources and methods

  • CHE’s Toxicant and Disease Database evaluates existing evidence and categorizes that evidence based on its strength. It is constructed using expert judgment and epidemiological causal inference.
  • The CTD, in contrast, is a continually updated resource that presents information on a broad range of literature on chemical-disease relationships. It also provides data on genes, biological processes, and phenotypes related to chemicals and diseases. It does not categorize information based on strength of evidence,  include an expert judgment process, or draw causal conclusions about toxicant-disease relationships.
  • The link we have provided on this page goes directly to CTD's curated results, which are a subset of the information available through CTD. Curated results in CTD are those for which studies are available on the toxicant-disease relationship.

References for our 2011 disease list

Correa A, Gray RH, Cohen R, Rothman N, Shah F, Seacat H, Corn M. Ethylene glycol ethers and risks of spontaneous abortion and subfertility. American Journal of Epidemiology, 1996. 143(7): p. 707-717.

El-Zein RA, Abdel-Rahman SZ, Morris DL, Legator MS. Exposure to ethylene glycol monomethyl ether: clinical and cytogenetic findings. Archives of Environmental Health. 2002 Jul-Aug;57(4):371-6.

Integrated Risk Information System (IRIS). IRIS Assessments. Accessed in 2010.

Klaassen CD, Ed. Casarett and Doull's Toxicology: The Basic Science of Poisons, 6th Edition. New York: McGraw-Hill 2001.

LaDou J, Ed. Occupational and Environmental Medicine, 3rd Edition. New York: Lange Medical/McGraw-Hill Company, 2004.

Landrigan PJ, Garg A. Chronic effects of toxic environmental exposures on children's health. Journal of Toxicology. Clinical Toxicology. 2002;40(4):449-56.

Rom WM. Environmental and Occupational Medicine, 3rd Edition. Philadelphia: Lippincott Williams & Wilkins Publishers, 1998.