Toxicant and Disease Database
The CHE Toxicant and Disease Database is a searchable database that summarizes links between chemical contaminants and approximately 180 human diseases or conditions. Diseases and or toxicants can be viewed by utilizing the search options below. See a full description of the database and our methodology.
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Acroosteolysis (vinyl chloride disease)
Causes Grouped by strength of evidence
Affected workers polymerizing vinyl chloride in 1960's. Patients developed finger parathesias, cold sensitivity, Raynaud's phenomenon, pseudo-clubbing of the fingers, and skin edema and thickening of the fingers, hands, and forearms. Increased prevalence noted in HLA DR3 and DR3/B8 haplotypes.