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Asthma - allergen, sensitizer

Causes [strength of evidence]:

Allergens causing allergic asthma can also cause allergic rhinitis. Over 250 agents have been documented to cause immunological occupational asthma, a few broad categories are included here. The haplotype HLA DQB1*0503 is associated with TDI asthma, while allele DQB1*0501 confers protection to TDI. The Th2 type of T helper cells has been associated with an increased likelihood of developing allergies and asthma. Air pollutants may act in conjunction with common allergens to increase sensitivity to other common allergens.

  • Amercian Academy of Pediatrics, Committee on Environmental Health. Ambient Air Pollution: Health Hazards to Children. Pediatrics 2004; 114(6):1699-1707.
  • Bornehag, CG. et al. The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study. Environ Health Perspect 2004; 112(14):1393-1397.
  • Brunekeef B, Holgate S. Air pollution and health. Lancet. 2002 Oct 19;360(9341):1233-42.
  • Integrated Risk Information System (IRIS)
  • Leikauf, G.D. Hazardous Air Pollutants and Asthma. Environ Health Perspect 2002;110(4):505-526.
  • Solomon, G. Asthma and the Environment. Peer-reviewed report for the Collaborative on Health and the Environment. Website: http://www.protectingourhealth.org/newscience/asthma/2003-04peerreviewasthma.htm 04/2003.

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