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Asthma - allergen, sensitizer

Causes [strength of evidence]:

Notes
Allergens causing allergic asthma can also cause allergic rhinitis. Over 250 agents have been documented to cause immunological occupational asthma, a few broad categories are included here. The haplotype HLA DQB1*0503 is associated with TDI asthma, while allele DQB1*0501 confers protection to TDI. The Th2 type of T helper cells has been associated with an increased likelihood of developing allergies and asthma. Air pollutants may act in conjunction with common allergens to increase sensitivity to other common allergens.

References:
  • Amercian Academy of Pediatrics, Committee on Environmental Health. Ambient Air Pollution: Health Hazards to Children. Pediatrics 2004; 114(6):1699-1707.
  • Bornehag, CG. et al. The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study. Environ Health Perspect 2004; 112(14):1393-1397.
  • Brunekeef B, Holgate S. Air pollution and health. Lancet. 2002 Oct 19;360(9341):1233-42.
  • Integrated Risk Information System (IRIS)
  • Leikauf, G.D. Hazardous Air Pollutants and Asthma. Environ Health Perspect 2002;110(4):505-526.
  • Solomon, G. Asthma and the Environment. Peer-reviewed report for the Collaborative on Health and the Environment. Website: http://www.protectingourhealth.org/newscience/asthma/2003-04peerreviewasthma.htm 04/2003.

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