CHE Toxicant and Disease Database
Reduced fertility - female (infertility and subfertility)
Causes [strength of evidence]:
Notes
Women exposed to DDT in the womb have been shown to have reduced fertility (increased time to pregnancy) as adults.
References:
- Axmon, A., Thulstrup, A. M., Rignell-Hydbom, A., Pedersen, H. S., Zvyezday, V., Ludwicki, J. K., Jonsson, B. A., Toft, G., Bonde, J. P., & Hagmar, L. 2006. Time to pregnancy as a function of male and female serum concentrations of 2,2'4,4'5,5'-hexachloro
- Baker SR and Wilkinson CF, ed. The Effects of Pesticides on Human Health. Workshop Proceedings, Advances in Modern Environmental Toxicology XVIII. May 9-11, 1998. Princeton Science Publishing, Princeton.
- Beliles, R.P. Concordance across Species in the Reproductive and Developmental Toxicity of Tetrachloroethylene. Toxicol Ind Health 2002;18:91-106.
- Choy, C.M et al. Infertility, blood mercury concentrations and dietary seafood consumption: a case-control study. BJOG 2002; 109(10):1121-1125
- Cohn, B.A. et al. DDT and DDE exposure in mothers and time to pregnancy in daughters. Lancet 2003;361:2205-2206.
- Correa, A., et al., Ethylene glycol ethers and risks of spontaneous abortion and subfertility. Am J Epidemiol, 1996. 143(7): p. 707-717.
- Figa-Talamanca, I., M.E. Traina, and E. Urbani, Occupational Exposures to Metals, Solvents, and Pesticides: Recent Evidence on Male Reproductive Effects and Biological Markers. Occup Med, 2001. 51(3): p. 174-188.
- Greenlee, AR. et al. Risk factors for female infertility in an agricultural region. Epidemiol 2003; 14(4):429-436.
- Hruska, K.S., et al., Environmental Factors in Infertility. Clin Obstet Gynecol, 2000. 43(4): p. 821-829.
- Ichihara, G. Neuro-reproductive toxicities of 1-bromopropane and 2-bromopropane. Int Arch Occup Environ Health. 2005 Mar;78(2):79-96.
- Massaad, C. et al. How can chemical compounds alter human fertility? Eur J Obstet Gynecol Reprod Biol 2002;100:127-137.
- Sallmen, M., et al., Reduced fertility among women exposed to organic solvents. Am J Ind Med, 1995. 27(5): p. 699-713.
- Schettler, T. Infertility and Related Reproductive Disorders. Peer-reviewed report for Collaborative on Health and the Environment. Website: http://www.protectingourhealth.org/newscience/infertility/2003-04peerreviewinfertility.htm
- Sharara, F.I., D.B. Seifer, and J.A. Flaws, Environmental toxicants and female reproduction. Fertil Steril, 1998. 70(4): p. 613-22.
- Younglai, E.V., A.C. Holloway, and W.G. Foster, Environmental and occupational factors affecting fertility and IVF success. Hum Reprod Update, 2005. 11(1): p. 43-57.
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