CHE Toxicant and Disease Database
Reduced Fertility - Male (infertility and subfertility)
Causes [strength of evidence]:
Notes
Subpopulations of men with genetic polymorphisms in ion channel isoforms may be at a higher risk for sperm damage from heavy metal exposure. Exposure to pesticides in farming or pesticide application have been associated with reduced time to pregnancy. Studies have not identified particular pesticides or pesticide classes.
References:
- Al-Hiyasat, A.S., H. Darmani, and A.M. Elbetieha, Effects of bisphenol A on adult male mouse fertility. Eur J Oral Sci, 2002. 110(2): p. 163-7.
- Anway, M. D., Cupp, A. S., Uzumcu, M., & Skinner, M. K. 2005. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science, 308(5727): 1466-1469.
- Axmon, A., Thulstrup, A. M., Rignell-Hydbom, A., Pedersen, H. S., Zvyezday, V., Ludwicki, J. K., Jonsson, B. A., Toft, G., Bonde, J. P., & Hagmar, L. 2006. Time to pregnancy as a function of male and female serum concentrations of 2,2'4,4'5,5'-hexachloro
- Baker SR and Wilkinson CF, ed. The Effects of Pesticides on Human Health. Workshop Proceedings, Advances in Modern Environmental Toxicology XVIII. May 9-11, 1998. Princeton Science Publishing, Princeton.
- Carpenter D.O. et al. Understanding the Human Health Effects of Chemical Mixtures. Environ Health Perspect 2002;110(suppl 1)25-42.
- Choy, C.M et al. Infertility, blood mercury concentrations and dietary seafood consumption: a case-control study. BJOG 2002; 109(10):1121-1125
- Figa-Talamanca I. et al. Occupational Exposures to Metals, Solvents, and Pesticides: Recent Evidence on Male Reproductive Effects and Biological Markers. Occup Med 2001;51(3):174-188.
- Hruska, K.S., et al., Environmental Factors in Infertility. Clin Obstet Gynecol, 2000. 43(4): p. 821-829.
- Ichihara, G. Neuro-reproductive toxicities of 1-bromopropane and 2-bromopropane. Int Arch Occup Environ Health. 2005 Mar;78(2):79-96.
- Mattison, D.R. et al. Reproductive Toxicity: Male and Female Reproductive Systems as Targets for Chemical Injury. Med Clin North Am 1990;74(2):391-411.
- Sanborn, MS. et al. Systematic Review of Pesticide Human Health Effects. Ontario College of Family Physicians. April, 2004. Available at: http://www.ocfp.on.ca/English/OCFP/Communications/Publications/default.asp?s=1
- Schettler, T. Infertility and Related Reproductive Disorders. Peer-reviewed report for Collaborative on Health and the Environment. Website: http://www.protectingourhealth.org/newscience/infertility/2003-04peerreviewinfertility.htm
- Solomon G. et al. Pesticides and Human Health: A Resource for Health Professionals. A peer-reviewed report by Physicians for Social Responsibility (LA and Greater Bay Area chapters) and Californians for Pesticide Reform. 2000. Available on-line at: http:
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