CHE Toxicant and Disease Database
Testicular cancer
Causes [strength of evidence]:
Notes
^ - Group 2B human carcinogen (IARC), *4-COT is the metabolite of chlordimeform. Pesticide exposure in applicators, manufacturers, farmers and other occupations with diverse exposures to mixtures of pesticides has been associated with testicular ca. In these studies, it was not possible to correlate an individual pesticide exposure with disease. Parental exposure to pesticides has also been associated with testicular ca. in male offspring.
References:
- Baker SR and Wilkinson CF, ed. The Effects of Pesticides on Human Health. Workshop Proceedings, Advances in Modern Environmental Toxicology XVIII. May 9-11, 1998. Princeton Science Publishing, Princeton.
- Dich J. and Wiklund K. Prostate Cancer in Pesticide Applicators in Swedish Agriculture. The Prostate 1998;34:100-112.
- Fleming, L. et al. Cancer Incidence in a Cohort of Licensed Pesticide Applicators in Florida. J Occup Environ Med. 1999; 41(4):279-288.
- Hardell, L. et al. Increased Concentrations of Polychlorinated Biphenyls, Hexachlorobenzene, and Chlordanes in Mothers of Men with Testicular Cancer. Environ Health Perspect. 2003;111:930-934.
- Massaad, C. et al. How can chemical compounds alter human fertility? Eur J Obstet Gynecol Reprod Biol 2002;100:127-137.
- Mehlman, M.A. Carcinogenicity of Methyl-Tertiary Butyl Ether in Gasoline. 2002;982:149-159.
- Rice, JM. The carcinogenicity of acrylamide. Mutat Res 2005; 580(1-2):3-20.
- Solomon G. et al. Pesticides and Human Health: A Resource for Health Professionals. A peer-reviewed report by Physicians for Social Responsibility (LA and Greater Bay Area chapters) and Californians for Pesticide Reform. 2000. Available on-line at: http:
- Wartenberg D. et al. Trichloroethylene and Cancer: Epidemiologic Evidence. Environ Health Perspect 2000;108(Suppl 2):161-176.
- Zahm W. and Hoar S. Pesticides and Childhood Cancer. Environ Health Perspect 1998;106(Suppl 3):893-908.
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