CHE Toxicant and Disease Database
Pancreatic cancer
Causes [strength of evidence]:
Notes
+ - Group 1 human carcinogen (IARC)
Organic solvent exposure in commercial pressmen and dry cleaners.
NNK is a tobacco specific nitrosamines
One case-control study found an association between organochlorine levels and K-ras mutations in pancreatic ca.
References:
- Cocco, P. et al Cancer Mortality and environmental Exposure to DDE in the United States. Environ Health Perspect 2000;108(1):1-4.
- Ji BT et al. Occupational exposure to Pesticides and Pancreatic Cancer. Am J Ind Med 2001;39(1):92-99.
- Kauppinen T. et al. Pancreatic Cancer and Occupational Exposures. Epidemiol 1995;6(5):498-502.
- Li, D. Molecular Epidemiology of Pancreatic Cancer. Cancer J. 2001;7:259-265.
- Lynge, E. et al. Organic Solvents and Cancer. Cancer Causes and Control 1997;8:406-419.
- Ojajariv A. et al. Risk of Pancreatic Cancer in Workers Exposed to Chlorinated Hydrocarbon Solvents and Related Compounds: A Meta-analysis. Am J Epidemiol 2001;153(9):841=50.
- Rice, JM. The carcinogenicity of acrylamide. Mutat Res 2005; 580(1-2):3-20.
- Wartenberg D. et al. Trichloroethylene and Cancer: Epidemiologic Evidence. Environ Health Perspect 2000;108(Suppl 2):161-176.
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