CHE Toxicant and Disease Database
Colo-rectal cancer
Causes [strength of evidence]:
Notes
Organic solvent exposure in commercial pressmen has been associated with colo-rectal cancer. Limited data showing association of colo-rectal ca in children with insecticide use. In addition to groups or individual pesticides listed, pesticide exposure in applicators, manufacturers and agricultural workers has been associated with colorectal ca. In these situations, the individual is exposed to mixtures of pesticides or different pesticides at different times and a correlation between an individual pesticide and disease can not be made.
References:
- Baker SR and Wilkinson CF, ed. The Effects of Pesticides on Human Health. Workshop Proceedings, Advances in Modern Environmental Toxicology XVIII. May 9-11, 1998. Princeton Science Publishing, Princeton.
- Bertazzi, P.A. et al. Health Effects of dioxin exposure: a 20-year mortality study. Am J Epidemiol 2001;153(11):1031-1044.
- Bondy, M.L. and Ismail, S. Serum organochlorine pesticide levels in patients with colorectal cancer in Egypt. Arch Environ Health 1997; 52(6):409-416.
- DeBruin L.S. and Josephy P.D. Perspectives on the Chemical Etiology of Breast Cancer. Environ Health Perspect 2002;110(Suppl 1):119-128.
- Lee, WJ. et al. Cancer Incidence among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study. J Natl Cancer Inst. 2004;96(23):1781-1789.
- Lynge, E. et al. Organic Solvents and Cancer. Cancer Causes and Control 1997;8:406-419.
- Morris, RD. Drinking water and cancer. Environ Health Perspect. 1995;103(S8):225-231.
- Solomon G. et al. Pesticides and Human Health: A Resource for Health Professionals. A peer-reviewed report by Physicians for Social Responsibility (LA and Greater Bay Area chapters) and Californians for Pesticide Reform. 2000. Available on-line at: http:
- Vincenti, M. et al. A retrospective cohort study of trihalomethane exposure through drinking water and cancer mortality in northern Italy. Sci Total Environ 2004;330(1-3):47-53.
- Zahm W. and Hoar S. Pesticides and Childhood Cancer. Environ Health Perspect 1998;106(Suppl 3):893-908.
- Zhong, Y. and Rafnsson, V. Cancer Incidence among Icelandic Pesticide Users. Int J Epidemiol 1996; 25:1117-1124.
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