CHE Toxicant and Disease Database
Bladder cancer
Causes [strength of evidence]:
Notes
+ - Group 1 human carcinogen, # - Group 2A human carcinogen, ^ - Group 2B human carcinogen (IARC) '*4-COT is the metabolite of chlordimeform Genetic differences in N-acetyltransferase, which detoxifies carcinogens, explain some variability in risk of disease. Individuals who are 'slow' acetylators have a greater susceptibility to bladder cancer than 'fast' acetylators. In addition to groups or individual pesticides listed, pesticide exposure in applicators, manufacturers and agricultural workers has been associated with bladder cancer. In these situations, the individual is exposed to mixtures of pesticides or different pesticides at different times. A correlation between an individual pesticide and disease can not be made. The link with propoxur is based on animal studies
References:
- Baker SR and Wilkinson CF, ed. The Effects of Pesticides on Human Health. Workshop Proceedings, Advances in Modern Environmental Toxicology XVIII. May 9-11, 1998. Princeton Science Publishing, Princeton.
- California Proposition 65
- Cohen S.M et al. Epidemiology and Etiology of Premalignant and Malignant Urothelial Changes. Scand J Urol Nephrol Suppl 2000; 205:105-115.
- Dich, J. et al. Pesticides and Cancer. Cancer Causes and Control 1997;8:420-443.
- Golka K., et al. The Enhanced Bladder Cancer Susceptibility of NAT2 Slow Acetylators Towards Aromatic Amines: a Review Considering Ethnic Differences. Toxicol Lett 2002;128(1-3):229-241.
- Goyer, R.A. Envrionmentally Related Diseases of the Urinary Tract. Med Clin North Am 1990;74(2):377-389.
- International Agency for Research on Cancer (IARC)
- Morris, RD. Drinking water and cancer. Environ Health Perspect. 1995;103(S8):225-231.
- Solomon G. et al. Pesticides and Human Health: A Resource for Health Professionals. A peer-reviewed report by Physicians for Social Responsibility (LA and Greater Bay Area chapters) and Californians for Pesticide Reform. 2000. Available on-line at: http:
- Villanueva, CM et al. Bladder cancer and exposure to water disinfection by-products through ingestion, bathing, showering, and swimming in pools. Am J Epidemiol. 2007 Jan 15;165(2):148-56
- Villanueva, CM. et al. Disinfection byproducts and bladder cancer: a pooled analysis. Epidemiology 2004;15(3):357-367.
- Vincenti, M. et al. A retrospective cohort study of trihalomethane exposure through drinking water and cancer mortality in northern Italy. Sci Total Environ 2004;330(1-3):47-53.
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