CHE Toxicant and Disease Database
Acroosteolysis (vinyl chloride disease)
Causes [strength of evidence]:
Notes
Affected workers polymerizing vinyl chloride in 1960's. Patients developed finger parathesias, cold sensitivity, Raynaud's phenomenon, pseudo-clubbing of the fingers, and skin edema and thickening of the fingers, hands, and forearms. Increased prevalence noted in HLA DR3 and DR3/B8 haplotypes.
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