CHE Toxicant and Disease Database
Immune suppression *
Causes [strength of evidence]:
Notes
* Broad non-specific category that includes decreased levels of circulating immune cells (including white blood cells), decreased levels of circulating antibodies, altered cell function, decreased immune response, decreased resistance to infection, and increased tumor susceptibility. In mice, allelic variation in the Ah receptor has been shown to confer different sensitivities to TCDD. At high concentrations, metals usually exert immunosuppresive effects; however, at lower concentrations immunoenhancement has been observed.
References:
- Baker SR and Wilkinson CF, ed. The Effects of Pesticides on Human Health. Workshop Proceedings, Advances in Modern Environmental Toxicology XVIII. May 9-11, 1998. Princeton Science Publishing, Princeton.
- Blakley, B. et al. Immnotoxicity of pesticides: a review. Toxicol Ind Health 1999;15:119-132.
- Cooper, G.S. et al. Occupational Exposures and Autoimmune Diseases. International Immunopharmacology 2002;2:303-313.
- Holladay, S.D. Prenatal Immunotoxicant Exposure and Postnatal Autoimmune Disease. Environ Health Perspect 1999; 107(suppl 5):687-691.
- Maves, M.D. Epidemiologic Studies of Environmental Agents and Systemic Autoimmune Diseases. Environ Health Perspect 1999;107(suppl 5):743-748.
- Rusiecki, JA. et al. Cancer Incidence Among Pesticide Applicators Exposed to Atrazine in the Agricultural Health Study. Environ Health Perspect. 2004;96(18):1375-1382.
- Sanborn, MS. et al. Systematic Review of Pesticide Human Health Effects. Ontario College of Family Physicians. April, 2004. Available at: http://www.ocfp.on.ca/English/OCFP/Communications/Publications/default.asp?s=1
- Solomon G. et al. Pesticides and Human Health: A Resource for Health Professionals. A peer-reviewed report by Physicians for Social Responsibility (LA and Greater Bay Area chapters) and Californians for Pesticide Reform. 2000. Available on-line at: http:
- Trask C.L. and Kosofsky B.E. Developmental Considerations of Neurotoxic Exposures. Neurologic Clinics 2000; 18(3):541-562.
|
|
Links to other Databases and Resources
About the database
Database home page
|
