CHE Toxicant and Disease Database
Autoimmune antibodies (positive ANA, anti-DNA, RF, etc.)
Causes [strength of evidence]:
Notes
Although the presence of auto-antibodies is a part of the diagnosis of autoimmune disease, the relevance of auto-antibodies in otherwise health individuals is unknown. Mercury-induced autoimmunity has a strong genetic component. Some strains of rats are completely resistant while others are exquisitely sensitive to mercury toxicity. Susceptibility has been linked to MHC and non-MHC genes.
References:
- Baker SR and Wilkinson CF, ed. The Effects of Pesticides on Human Health. Workshop Proceedings, Advances in Modern Environmental Toxicology XVIII. May 9-11, 1998. Princeton Science Publishing, Princeton.
- Cooper, G.S. et al. Occupational Exposures and Autoimmune Diseases. International Immunopharmacology 2002;2:303-313.
- D'Cruz, D. Autoimmune Diseases Associated with Drugs, Chemicals, and Environmental Factors. Toxicology Letters 2000; 112-113: 421-432.
- Maves, M.D. Epidemiologic Studies of Environmental Agents and Systemic Autoimmune Diseases. Environ Health Perspect 1999;107(suppl 5):743-748.
- Pfau, JC. et al. Assessment of autoimmune responses associated with asbestos exposure in Libby, Montana. USA. Environ Health Perspect 2005;113(1):25-30.
- Solomon, G. Asthma and the Environment. Peer-reviewed report for the Collaborative on Health and the Environment. Website: http://www.protectingourhealth.org/newscience/asthma/2003-04peerreviewasthma.htm 04/2003.
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