CHE Toxicant and Disease Database
Porphyria (toxic)
Causes [strength of evidence]:
Notes
Hexachlorobenzene exposure in adults results in cutaneous photosensitivity and porphyrinuria. However, in infants, exposure results in high mortality and neurotoxicity (convulsions) without porphyrinuria. Aluminum inhibits some heme synthetic enzymes and has been implicated in causing porphyria in chronic hemodialysis patients, whom are often aluminum overloaded. Lead intoxication causes signs and symptoms similar to acute intermittent porphyria including abdominal pain, constipation and vomiting. However, anemia which is often found with lead intoxication is virtually absent in porphyria.
References:
- Leikin, J.B et al. Selected Topics Related to Occupational Exposures. Part IV. Occupational Liver Disease. Dis Mon 2000;46(4):296-310.
- Solomon G. et al. Pesticides and Human Health: A Resource for Health Professionals. A peer-reviewed report by Physicians for Social Responsibility (LA and Greater Bay Area chapters) and Californians for Pesticide Reform. 2000. Available on-line at: http:
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