CHE Toxicant and Disease Database
Myocardial infarction (Heart attack)
Causes [strength of evidence]:
Notes
People with pre-existing heart disease are more susceptible to the ischemic effects of carbon monoxide. Dichloromethane (methylene chloride) and dihalomethanes are metabolized to carbon monoxide in the body. Organic nitrates exposure (mainly in the explosives industry) includes ammonium, sodium nitrate, ethylene glycol dinitrate, nitroglycerin, and TNT and can cause cardiotoxicity in the absence of heart disease.
References:
- Brautbar, N. and Howard, J. Phosphine Toxicity: Report of two Cases and Review of the Literature. Toxicol Ind Health 2002;18:71-75.
- Brunekeef B, Holgate S. Air pollution and health. Lancet. 2002 Oct 19;360(9341):1233-42.
- Leikin, J.B., et al. Selected Topics Related to Occupational Exposures. Part V. Occupational Cardiovascular Disease. Dis Mon 2000;46(4):311-322.
- Menke A, Muntner P, Batuman V, Silbergeld EK, Guallar E. Blood lead below 0.48 micromol/L (10 microg/dL) and mortality among US adults Circulation. 2006 Sep 26;114(13):1388-94.
- Miller, KA et al. Long-term exposure to air pollution and incidence of cardiovascular events in women. N Engl J Med. 2007 Feb 1;356(5):447-58.
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