CHE Toxicant and Disease Database
Diabetes - Type II
Causes [strength of evidence]:
- arsenic [Strong]
- Dioxins/TCDD [Good]
- Tobacco smoke [Good]
- 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (HpCDD) [Limited]
- 2,2,4,4,5,5-hexachlorobiphenyl (PCB153) [Limited]
- DDT/DDE [Limited]
- iron [Limited]
- Octachlorodibenzo-p-dioxin [Limited]
- oxychlordane [Limited]
- transnonachlor [Limited]
Notes
^ These chemicals were examined as a group not individually
References:
- Bertazzi, P.A. et al. Health Effects of dioxin exposure: a 20-year mortality study. Am J Epidemiol 2001;153(11):1031-1044.
- Kouznetsova, M et al. Increased rate of hospitalization for diabetes and residential proximity of hazardous waste sites. Environ Health Perspect. 2007 Jan;115(1):75-9.
- Lee, DH et al. A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002. Diabetes Care. 2006 Jul;29(7):1638-44.
- Longnecker, M.P. and Daniels, J.L. Environmental Contaminants as Etiologic Factors for Diabetes. Environ Health Perspect 2001; 109 (suppl 6):871-876.
- Remillard, R.B.J. and Bunce, N.J. Linking Dioxins to Diabetes: Epidemiology and Biologic Plausibility. Environ Health Perspect 2002; 110:853-858.
- Tseng C.H., et al. Epidemiological Evidence of Diabetogenic Effect of Arsenic. Toxicol Letters 2002;133:69-76.
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