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Fertility/Reproductive Health
Working Group

CHE's Fertility & Reproductive Health Working Group convenes over 450 diverse members around environmental impacts on fertility and reproductive health. The goal of this dynamic conversation is to discern what the science is telling us, where the research gaps are, and how we can effectively support and promote science-based education and action. Read more...

If you would like to join and are already a CHE Partner, send us an email request. Or become a CHE Partner and indicate your interest in your application.

For more information, please contact Karin Russ at karin@healthandenvironment.org.

WHAT'S NEW

Highlights, November 2014

San Francisco Medical Society journal focuses on environmental health
San Francisco Medicine (SFM), which has been in continuous publication since 1927, is the official journal of the San Francisco Medical Society. Each issue of SFM focuses on a specific topic that affects physicians and their practices, including public health, social, political, economic, and lifestyle issues. The most recent edition of the journal focuses on environmental health and features an article titled The First 1000 Days: A Healthy Return on Investment co-authored by Elise Miller, MEd, CHE's Director, and Ted Schettler, MD, MPH, Science Director at SEHN and at CHE, as well as many other articles that will be of interest to CHE Partners. Visit the San Francisco Medical's Society website to read the full edition.

Reproductive Environmental Health articles: Early life exposures altered breast development

Estrogens in the wrong place at the wrong time: fetal BPA exposure and mammary cancer
Gestational exposure of rodents the xenoestrogen bisphenol-A (BPA) increases the propensity to develop mammary cancer during adulthood, long after cessation of exposure. Exposure to BPA during gestation induces morphological alterations in both the stroma and the epithelium of the fetal mammary gland at 18 days of age. BPA is postulated to affect the hypothalamus and thus in turn affect the regulation of mammotropic hormones at puberty and beyond. Reproductive Toxicology.

In utero exposure and breast cancer development: an epigenetic perspective
The information contained in this non-systematic review highlights and expands on the estrogen-based model of breast cancer epigenetics to provide an overview of epigenetic alterations induced by nutrition and environmental exposure. The majority of evidence suggests that various sources of excess estrogen correlate to future breast cancer development. In addition, maternal macro- and micronutrient balance appear to play a role in genomic regulation, and preliminary data suggest that specific superfoods, such as blueberries, have a protective epigenetic effect.  Journal of Environmental Pathology, Toxicology and Oncology.

Polybrominated biphenyl ether (DE-71) interferes with thyroid hormone action independent of effects on circulating levels of thyroid hormone in male rats
PBDEs may interfere with thyroid hormone (TH) during development, which could produce neurobehavioral deficits. In this study, PBDE exposure reduced serum T4 but did not produce effects on tissues typical of low TH. Endocrinology.

Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors
A large genotyping project within the Breast Cancer Association Consortium (BCAC) recently identified 41 associations between single nucleotide polymorphisms (SNPs) and overall breast cancer (BC) risk. None of the observed interactions was significant after accounting for multiple testing. In conclusion, recently identified BC susceptibility loci are not strongly modified by established risk factors and the observed potential interactions require confirmation in independent studies. International Journal of Cancer.

See a searchable calendar with events of interest to this working group.

UCSF Program on Reproductive Health and the Environment present Visionary Leadership Awards

6/14/13: The UCSF PRHE program awarded its Visionary Leadership Award at the start of The Endocrine Society Meeting in San Francisco to three prominent leaders of professional societies. Teresa Woodruff, President-elect of The Endocrine Society, Linda Giudice, President of the American Society for Reproductive Medicine, and Jeanne Conry, President of the American Congress of Obstetricians and Gynecologists were this year's recipients. The award is given to visionary leaders working to improve reproductive health by preventing harmful environmental exposures.

Pictured above (L-R) are PRHE Director, Tracey Woodruff with Linda Giudice and CHE Fertility founder, Alison Carlson. Below, Vice-Chair of CHE Michael Lerner, Alison Carlson, former CHE Fertility coordinator Julia Varshavsky, and current coordinator Karin Russ gather to commemorate the occasion.

Second Annual CHE/NIEHS Women's Environmental Reproductive Health Consortium Meeting

For additional information, visit: Women's Environmental Reproductive Health Consortium. 
 

 

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