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Fertility/Reproductive Health
Working Group

CHE's Fertility & Reproductive Health Working Group convenes over 450 diverse members around environmental impacts on fertility and reproductive health. The goal of this dynamic conversation is to discern what the science is telling us, where the research gaps are, and how we can effectively support and promote science-based education and action. Read more...

If you would like to join and are already a CHE Partner, send us an email request. Or become a CHE Partner and indicate your interest in your application.

For more information, please contact Karin Russ at karin@healthandenvironment.org.


Highlights, March 2015

Reproductive Health and the Environment: Best Practices for Los Angeles County
March 17th, 8:00 a.m. – 2:00 p.m.  Sponsors: the Iris Cantor - UCLA Women's Health Education & Resource Center, the LA County Department of Public Health's Office of Women's Health, Black Women for Wellness, and Physicians for Social Responsibility – Los Angeles.
You are invited to a free conference that will bring together health professionals, community activists, researchers, academicians, civic and business leaders, politicians, and government officials to learn about best practices related to research, policy, and community advocacy. Register here.

Fertility and reproductive health related artiles - developmental origins of health and disease

Developmental origins of health and disease: a paradigm for understanding disease cause and prevention
This review will focus on the role of altered nutrition and exposures to environmental chemicals during development in the role of disease and dysfunction. The evidence in support of the developmental origins of the health and disease paradigm is sufficiently robust and repeatable across species, including humans, to suggest a need for greater emphasis in the clinical area. As a result of these data, obesity, diabetes, cardiovascular morbidity, and neuropsychiatric diseases can all be considered pediatric diseases. Disease prevention must start with improved nutrition and reduced exposure to environmental chemicals during development. Current Opinion in Pediatrics.

Recent progress in the genetics and epigenetics of paraoxonase: why it is relevant to children's environmental health
Novel discoveries in the field of molecular epidemiology that can help explain susceptibility to exposures and disease will be demonstrated using the multifunctional enzyme paraoxonase 1 (PON1) as an example. This PON1 model demonstrates that integrating genetic and epigenetic factors, as well as other novel methodologies, can improve our understanding of important susceptibility factors linked to pediatric disease. Current Opinion in Pediatrics.

Metabolomics in the developmental origins of obesity and its cardiometabolic consequences
This review examines the potential role of metabolomics to enhance understanding of obesity-related developmental origins of health and disease (DOHaD). Authors describe how metabolomics may capture exposures that are notoriously difficult to quantify, and help to further refine phenotypes associated with excess adiposity and related metabolic sequelae over the life course. Together, these data can ultimately help to elucidate mechanisms that underlie fetal metabolic programming. Journal of Developmental Origins of Health and Disease.

The developmental origins of chronic physical aggression: biological pathways triggered by early life adversity
Longitudinal epidemiological studies with birth cohorts have shown that physical aggression in humans does not appear suddenly in adolescence as commonly thought. In fact, physically aggressive behaviour is observed as early as 12 months after birth. Recent evidence suggests that epigenetic mechanisms are responsive to adverse environments and could be involved in the development of chronic aggression. Journal of Experimental Biology.

Influence of environmental exposure on human epigenetic regulation
This review will highlight research on epigenomic profiles in human populations set during the in utero period. The impact of environmental toxicants, including cigarette smoke and toxic trace metals such as arsenic, mercury and manganese, on genome-wide, gene-specific DNA methylation has been assessed. The results suggest that in humans, like other vertebrates, there is susceptibility for epigenomic alteration by the environment during intrauterine development. Journal of Experimental Biology

Gene-Environment Interactions Controlling Energy and Glucose Homeostasis and the Developmental Origins of Obesity
Obesity and type 2 diabetes mellitus (T2DM) often occur together and affect a growing number of individuals in both the developed and developing worlds. Both are associated with a number of other serious illnesses that lead to increased rates of mortality. This review focuses on the many genetic and environmental variables that interact to cause predisposed individuals to become obese and diabetic. Physiological Reviews.

See a searchable calendar with events of interest to this working group.

UCSF Program on Reproductive Health and the Environment present Visionary Leadership Awards

6/14/13: The UCSF PRHE program awarded its Visionary Leadership Award at the start of The Endocrine Society Meeting in San Francisco to three prominent leaders of professional societies. Teresa Woodruff, President-elect of The Endocrine Society, Linda Giudice, President of the American Society for Reproductive Medicine, and Jeanne Conry, President of the American Congress of Obstetricians and Gynecologists were this year's recipients. The award is given to visionary leaders working to improve reproductive health by preventing harmful environmental exposures.

Pictured above (L-R) are PRHE Director, Tracey Woodruff with Linda Giudice and CHE Fertility founder, Alison Carlson. Below, Vice-Chair of CHE Michael Lerner, Alison Carlson, former CHE Fertility coordinator Julia Varshavsky, and current coordinator Karin Russ gather to commemorate the occasion.

Second Annual CHE/NIEHS Women's Environmental Reproductive Health Consortium Meeting

For additional information, visit: Women's Environmental Reproductive Health Consortium. 


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