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February 25, 2015 --

CHE Fertility Working Group call: Placental Toxicants and Disruption to Development
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Fertility/Reproductive Health
Working Group

CHE's Fertility & Reproductive Health Working Group convenes over 450 diverse members around environmental impacts on fertility and reproductive health. The goal of this dynamic conversation is to discern what the science is telling us, where the research gaps are, and how we can effectively support and promote science-based education and action. Read more...

If you would like to join and are already a CHE Partner, send us an email request. Or become a CHE Partner and indicate your interest in your application.

For more information, please contact Karin Russ at karin@healthandenvironment.org.

WHAT'S NEW

Highlights, January 2015

CEHN Research Conference: Children: Food and Environment
Children's Environmental Health Network; February 4-6, 2015; Austin, Texas. This exciting conference will highlight cutting edge science and offer the translation of findings to public health practice and policy. The conference program will organize around specified health and developmental outcomes or affected organ/body systems, and include presentations on micro-level influences such as nutrient mediated microbiome effects as well as macro-level influences such as contaminants rising from modern food production practices. Co-sponsored by Environmental Health Perspectives and the International Society for Children’s Health and the Environment.

CHE quarterly Top 10 list
CHE offers this selection of research, news and announcements that were of special significance during the fourth quarter of 2014. Items include research that made a noteworthy contribution to the field, news and announcements that took a conversation to a new level and/or new audience and some welcome action. Visit the CHE blog to see this quarter's list. We invite comment and feedback.

Five Major Health Threats from Fracking-Related Air Pollution: Analysis of the science to-date
A growing body of evidence shows that people both near and far from oil and gas drilling are exposed to fracking-related air pollution that can cause at least five major types of health impacts, according to a new comprehensive analysis of scientific studies to-date by the Natural Resources Defense Council.  The health impacts include respiratory problems, birth defects, blood disorders, cancer and nervous system impacts, raising serious concerns for workers and people living closest to wells, as well as entire regions with high volumes of oil and gas activity.

Employment opportunity: CEHN Engagement Manager for Eco-Healthy Child Care® Program
This position is an important and visible part of CEHN’s team, publicly represent CEHN while participating in meetings with federal and national association partners; presenting at national conferences; and conducting state-wide trainings. Based in Washington, D.C.; some travel required.

Reproductive environmental health articles: Reproductive and developmental toxicity

Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish
Researchers demonstrate that bisphenol A (BPA) exposure during a time point analogous to the second trimester in humans has real and measurable effects on brain development and behavior. This data, combined with over a dozen physiological and behavioral human studies that begin to point to the prenatal period as a BPA window of vulnerability, suggest that pregnant mothers limit exposure to plastics and receipts. Proceedings of the National Academy of Sciences.   

Adult exposure to bisphenol A (BPA) in Wistar rats reduces sperm quality with disruption of the hypothalamic-pituitary-testicular axis
The objective of this study was to investigate the reproductive toxicity of BPA at dosages considered to be safe. These data suggest that at dosages previously considered nontoxic to reproductive function, BPA compromises the spermatozoa and disrupts the hypothalamic-pituitary-gonadal axis, causing a state of hypogonadotropic hypogonadism. Toxicology.

Combined effects of repeated administration of Bretmont Wipeout (glyphosate) and Ultrazin (atrazine) on testosterone, oxidative stress and sperm quality of Wistar rats
Researchers evaluated reproductive- and hepato-toxicity in rats co-exposed to ATZ and GLY. Oxidative stress and histopathological changes were noticeable in the liver but not in the testis of GLY-treated animals, and the observed effects were more remarkable in the GLY group than the ATZ or the combined-exposure group. The combined effects of the active ingredients on testosterone level, sperm count and hepatic malondialdehyde (MDA) levels were also similar as when the commercial formulations were used. Toxicology, Mechanisms and Methods.

Leydig cell number and sperm production decrease induced by chronic ametryn exposure: a negative impact on animal reproductive health
Ametryn is an herbicide used to control broadleaf and grass weeds and its acute and chronic toxicity is expected to be low. These results showed negative ametryn influence on the testes and can compromise animal reproductive performance and survival. Environmental Science and Pollution Research International

A high throughput screening system for predicting chemically-induced reproductive organ deformities
There is a great need for alternative testing methods for reproductive toxicants that are practical, fast, cost-effective and easy to interpret. The most informative assays in the battery were ERalpha CALUX reporter gene assay to measure estrogenicity and the AR-anti CALUX assay to measure androgen receptor antagonism. Reproductive Toxicology

Developmental and reproductive effects of chemicals associated with unconventional oil and natural gas operations
In this work, we review the scientific literature providing evidence that adult and early life exposure to chemicals associated with UOG operations can result in adverse reproductive health and developmental effects in humans. Volatile organic compounds (VOCs) [including benzene, toluene, ethyl benzene, and xylene (BTEX) and formaldehyde] and heavy metals (including arsenic, cadmium and lead) are just a few of the known contributors to reduced air and water quality that pose a threat to human developmental and reproductive health. Reviews on Environmental Health.

See a searchable calendar with events of interest to this working group.

UCSF Program on Reproductive Health and the Environment present Visionary Leadership Awards

6/14/13: The UCSF PRHE program awarded its Visionary Leadership Award at the start of The Endocrine Society Meeting in San Francisco to three prominent leaders of professional societies. Teresa Woodruff, President-elect of The Endocrine Society, Linda Giudice, President of the American Society for Reproductive Medicine, and Jeanne Conry, President of the American Congress of Obstetricians and Gynecologists were this year's recipients. The award is given to visionary leaders working to improve reproductive health by preventing harmful environmental exposures.

Pictured above (L-R) are PRHE Director, Tracey Woodruff with Linda Giudice and CHE Fertility founder, Alison Carlson. Below, Vice-Chair of CHE Michael Lerner, Alison Carlson, former CHE Fertility coordinator Julia Varshavsky, and current coordinator Karin Russ gather to commemorate the occasion.

Second Annual CHE/NIEHS Women's Environmental Reproductive Health Consortium Meeting

For additional information, visit: Women's Environmental Reproductive Health Consortium. 
 

 

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