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Fertility/Reproductive Health
Working Group

CHE's Fertility & Reproductive Health Working Group convenes over 450 diverse members around environmental impacts on fertility and reproductive health. The goal of this dynamic conversation is to discern what the science is telling us, where the research gaps are, and how we can effectively support and promote science-based education and action. Read more...

If you would like to join and are already a CHE Partner, send us an email request. Or become a CHE Partner and indicate your interest in your application.

For more information, please contact Karin Russ at karin@healthandenvironment.org.


Highlights, August 2015

CHE quarterly Top 10 environmental health stories now available
CHE offers this selection of research, news and announcements that were of special significance during the second quarter of 2015. Items include research that made a noteworthy contribution to the field, news and announcements that took a conversation to a new level, and/or new audience and some welcome action. This quarter's selections include the Pope's contribution to the climate change discussion, a study relating DDT exposure in pregnancy to breast cancer rates in daughters, the US House's efforts to pass TSCA reform, and others. Visit the CHE blog to see this quarter's list. We invite comment and feedback.

MP3 recording now available: News from the US EPA Endocrine Disruptor Screening Program
On this call Dr. James Cowles of the EPA’s Environmental Fate and Effects Division presented information on the current status of screening, including the anticipated release of preliminary results. Dr. David Dix of the EPA’s Office of Science Coordination and Policy Office of Chemical Safety and Pollution Prevention explored future directions in screening for endocrine disruption.

CHE blog column: Your Health This Week
CHE offers this weekly column on the CHE Blog highlighting studies and resources that you might find useful in safeguarding or improving your own health or that of your family.

New publications of interest with a focus on male fertility:

Oestrogen action and male fertility: experimental and clinical findings
Recent data from genetically modified mice and human infertile patients have shown that oestrogens may promote the engulfment of live Leydig cells by macrophages leading to male infertility. We also discuss recent data on environmental oestrogen exposure in men and rodents, where a rodent-human distinction is crucial and analyse some aspects of male fertility potentially related to impaired oestrogen/androgen balance. Cell Mol Life Sci.

Phthalate exposure and human semen quality: Results from an infertility clinic in China
Our findings suggest that environmental exposure to di-n-butyl phthalate (DBP) and DEHP may contribute to a decline in semen quality. Environ Res.

Fine particulate matter leads to reproductive impairment in male rats by overexpressing phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway
PM2.5 exposure leads to oxidative stress impairment via PI3K/Akt signaling pathway on male reproduction in rats. Toxicol Lett.

Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model
Exposure to a therapeutic dose of acetaminophen for 7 days significantly reduced plasma testosterone and seminal vesicle weight in castrate host mice bearing human fetal testis xenografts, whereas acetaminophen exposure for just 1 day did not alter either parameter.  Subsequent in utero exposure studies in rats indicated that the acetaminophen-induced reduction in testosterone likely results from reduced expression of key steroidogenic enzymes (Cyp11a1, Cyp17a1). Sci Transl Med.

Fluoride exposure changed the structure and the expressions of reproductive related genes in the hypothalamus-pituitary-testicular axis of male mice
The present study was to investigate the effects of fluoride exposure on the expressions of reproductive related genes, serum sex hormone levels and structures of the hypothalamus-pituitary-testicular axis (HPTA), which plays a vital role in regulating the spermatogenesis in male mice. Chemosphere.

Disturbance in testosterone production in leydig cells by polycyclic aromatic hydevrepocarbons
Of note, the testosterone level reductions were accompanied by decreased steroidogenic acute regulatory protein (StAR) and 3β-hydevrepoxysteroid dehydevrepogenase isomerase (3β-HSD) expression in Leydig cells. B[a]P exposure can decrease epididymal sperm quality, possibly by disturbing the testosterone level. StAR may be a key steroidogenic protein that is targeted by B[a]P or other PAHs. Balsaenggwa Saengsig.  Free PMC Article

See a searchable calendar with events of interest to this working group.

UCSF Program on Reproductive Health and the Environment present Visionary Leadership Awards

6/14/13: The UCSF PRHE program awarded its Visionary Leadership Award at the start of The Endocrine Society Meeting in San Francisco to three prominent leaders of professional societies. Teresa Woodruff, President-elect of The Endocrine Society, Linda Giudice, President of the American Society for Reproductive Medicine, and Jeanne Conry, President of the American Congress of Obstetricians and Gynecologists were this year's recipients. The award is given to visionary leaders working to improve reproductive health by preventing harmful environmental exposures.

Pictured above (L-R) are PRHE Director, Tracey Woodruff with Linda Giudice and CHE Fertility founder, Alison Carlson. Below, Vice-Chair of CHE Michael Lerner, Alison Carlson, former CHE Fertility coordinator Julia Varshavsky, and current coordinator Karin Russ gather to commemorate the occasion.

Second Annual CHE/NIEHS Women's Environmental Reproductive Health Consortium Meeting

For additional information, visit: Women's Environmental Reproductive Health Consortium. 


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