Welcome Claudia! I will be interested in your comments on TILT in children (0-18 yrs).

Claudia -- You were the first to report that most people with multiple chemical sensitivity experience a significant reduction in their tolerance for exposures to light and sound as well as chemicals. Others have since reported MCS associated with reduced tolerance to touch, pain, hot weather, and electro-magnetic fields. What do you think all these pathways have in common that makes them so susceptible to toxic exposure, and have you found any treatments that help people with such multi-sensory sensitivities recover their prior ("normal") levels of chemical and/or other sensory tolerances?

here is a link to a synopsis of the article I will be summarizing: http://www.environmentalhealthnews.org/newscience/2007/2007-0401naritaetal.html

I noticed People Magazine now tells readers to call tell them if they don't want to receive issues with perfume ads. Is this unusual and what does it mean in terms of acceptance of TILT?

where are the slides located?

Michael, you can link to the slides from this: http://healthandenvironment.org/articles/call_resources/1096

For Dr. Miller: I recall our brief conversation a few years ago about introducing your diagnostic tool for MCS and tolerances with the children from Ground Zero Schools. My sense is that, now, 5+ years later, might be a good time to explore those issues with families, esp now that funds have become available for tracking 9/11 health problems.

The slides are located on the CHE website at: http://healthandenvironment.org/articles/call_resources/1096. Click on "Slide Presentation" and they will download to your computer. The slides are in PDF format.

Are heavy fragrance users perhaps exhibiting the alternative "addiction" mechanism of continous exposure?

Following answer about autism related to pregnancy exposure; Would it be possible the mother not suffer expsosure effects but does effect baby? Also suggesting actual genetic changes may occur?

There are now many examples of exposures that don't cause measurable effect in mother but do effect the baby. This can happen without classic genetic changes, i.e., mutations. It typically takes high doses to cause mutations. Much lower doses, however, can cause changes in changes in the factors that control how genes are turned on and off, the effect of which can be just as powerful as mutations.

Is anyone else interested in researching whether heavy fragrance users go into withdrawal on "fresh air"? If the addiction model is valid, that might explain why accommodation efforts are practically impossible - imagine asking all smokers to give up smoking completely.

By Carl Grimes. You mentioned increased understanding of TILT by toxicologists. What is the key to helping them understand and accept the differences of traditional toxicology from TILT, especially the extremely low level of reactivity, intensification of reactions and the "windowing" effect.

Could TILT theory have implications for increasing risk of breast cancer and other cancers by damaging immune system?

Any connections between TILT and coronary artery disease, atherosclerosis, cholesterol?

I think that environmental etiologies of breast and other cancers will be individual -- as are the SNP's determining the detoxification of each person that will determine their unique susceptability. I have observed many people on the island of Martha's Vineyard to have breast cancer while living in a unhealthy moldy environment. The mycotoxin Ochratoxin has been proven to cause endometrial cancer and one woman here just died in a moldy home from that tumour quite rapidly. I know of at least 6 friends with breast CA who are very moldy environments and I hope that someone hears my thought on this subject and comes bearing funds and organizational skills to help me test this theory on patients here. The breast cancer rate is high in Long Island, the Vineyard and in Florida all of which are prone to mold. I will assist in what ever way I can. Even just doing a mold plate in each home could be informative. I'll do the work and you write it up! Lisa